car-t
2 stories tagged "car-t"
Cancer
Whether a T Cell Keeps Killing Cancer or Quits Is Written in How Its Genome Folds
Exhausted CD8 T cells are why checkpoint drugs and CAR-T so often stall. New maps of the 3D genome show their fate is set by how the DNA is physically folded, and by CTCF, the protein that does the folding.
CancerOne Protein Keeps Your T Cells in the Fight. The Same Protein Feeds Autoimmune Disease.
In mice, deleting the LEF1 gene collapsed the reserve T cells that sustain the fight against chronic infection and cancer. The same deletion protected against autoimmune diabetes.