Histamine Was Always the Wrong Target for the Eczema Itch
Eczema itch runs on cytokines, not mainly histamine, which is why the pills in the allergy aisle keep failing the trials, and a network meta-analysis just said so one more time.
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Pregnant Women's Blood Pressure Registers Every Smoke Day. A Federal Rule Lets States Erase Those Days From the Record.
On heavy smoke days, adults' systolic pressure ran nearly 4 mmHg higher; across eight southwestern states, gestational smoke exposure raised the odds of gestational hypertension 12 percent. Since 2016, regulators have won EPA approval to erase wildfire smoke from the Clean Air Act record in more tha
Drugs & FDAThe FDA Approved the First Cholesterol Pill of Its Kind Before Its Trial Could Show It Prevents Heart Attacks or Deaths
Lipfendra lowers LDL cholesterol by up to 60 percent. The 14,550-patient trial that would show whether that prevents heart attacks or deaths does not finish until November 2029, and Merck is charging roughly $3,800 a year in the meantime.
Nutrition & FoodThe NIH Weighed Every Meal to a Tenth of a Gram. Four AI Calorie Apps Undercounted by up to 345.
In a locked NIH metabolic kitchen where every ingredient was weighed to 0.1 grams, MyFitnessPal, Lose It!, CalAI, and Appediet each read a plate and undercounted it by a quarter to a third, missing the fat most of all.
CancerThe Same Cancer Mutation, Opposite Effects: What 581 Mouse Tumors Say About Who Gets Sick
Cambridge and Yale gave four strains of mice one identical dose of a carcinogen. The tumors converged on the same pathway but took four different genetic routes to get there, and today's screening ignores the reason.
InvestigationsBPA Sits in 90% of Us. The Cancer Studies Sample It With a Method That Was Never Going to Find Anything.
Bisphenol A shows up in more than nine of ten Americans, yet California's reviewers just called the cancer evidence 'inadequate,' because the studies measure a chemical the body clears in hours from a single urine sample.
InvestigationsThe American Diabetes Association Had Police Remove the Editor of Its Own Journal. Then It Refused to Print His Reply.
Steven Kahn edits the ADA's own journal. In June its meeting had state police walk him out for handing out one of its editorials. In July it refused to print the response he and his colleagues wrote. He calls it what it is: pure censorship.
InvestigationsA Gene-Editing Trial Killed a 6-Year-Old. Nature Published the Science and Left Her Out of the Record.
Her parents paid $860,000 to base-edit their daughter's brain. She died of an immune reaction within a week, the trial's fatal outcome was never disclosed, and the Nature paper built on the same work never names her.
Metabolic & WeightOrforglipron Reaches Deep Into the Brain's Reward Circuit and Turns the Dopamine Down
In mice engineered with human GLP-1 receptors, the new oral pills reached the central amygdala, a deep reward hub, and thinned the dopamine payoff of eating for pleasure. The government's addiction institute is already watching.
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