Autoimmune & Inflammation
45 stories
A Daily Fiber Powder Eased Knee Arthritis Pain, and People's Grip Got Stronger Too
Six weeks of inulin, a prebiotic sold by the tub, cut knee pain 1.11 points more than placebo and added 4.62 kilograms of grip strength in a Nottingham trial, while the gut hormone GLP-1 rose alongside.
Autoimmune & InflammationThe 10-Year Crohn's Prediction Model Has Never Left the Military Cohort That Built It
Antibodies against gut-bacteria flagella and Epstein-Barr virus shift years before Crohn's is diagnosed, but the models scoring an AUC of 0.90 were built and judged inside one mostly male group of U.S. service members, with no independent validation yet.
Autoimmune & InflammationArthritis From Cancer Immunotherapy Comes Back With the Same T Cell Clones
Joint fluid drawn at a first flare and again at a relapse held the same expanded T cell clones, with a stronger inflammatory signature the second time. The durable immune memory these cancer drugs are sold on has a cost in the joints.
Autoimmune & InflammationYour Celiac Blood Test Can Read Normal While Your Gut Stays Damaged
The standard antibody test can read perfectly normal while a celiac patient's intestine stays inflamed. In one Oslo cohort, a nine-protein blood signal tracked the damage the antibodies kept missing.
Autoimmune & InflammationThe Rogue Clones in Aging Blood Shrug Off the Inflammation That Wears Down Their Neighbors
By 70, more than half of people carry mutant blood-stem-cell clones on sensitive tests. Marrow maps show them living amid inflamed, fibroblast-rich pockets, and the mutants barely flinch at the inflammation.
Autoimmune & InflammationA Bacterial Syringe, a Mouse Gut Lining, and Eight Months of Immune Memory
In mice, the cells lining the colon present bacterial antigens themselves, and whether a lasting memory forms tracks with where inside the cell the antigen lands rather than how much of it arrives.
Autoimmune & InflammationNovartis Halted Eight Autoimmune CAR-T Trials After Three Deaths, Then Called the Killer a "Known Risk"
Three people in Novartis's rap-cel trials died after a runaway inflammatory syndrome, and Bristol Myers froze enrollment in its rival product. Faster manufacturing is the leading suspect, and no public report yet says how many patients got the drug.
Autoimmune & InflammationNovo Nordisk Paid to Count the Inflamed Heart Failure Patients Its Antibody Is Chasing
Three big studies putting heart failure inflammation anywhere from 38% to more than half were funded by Novo Nordisk, whose IL-6 antibody missed its first outcomes trial in July. Their predictor tables point at fat, smoking and kidneys.
Autoimmune & InflammationKnee Pain Fell From 7 to 3 After This Artery Procedure, but It Keeps Struggling to Beat a Fake One
Berlin doctors plugged inflamed knee vessels with gelatin beads built to dissolve within hours, and median pain fell from 7 to 3 over a year. Nobody got a sham, and the Rotterdam trial that used one calls the effect mainly placebo.
Autoimmune & InflammationA Few Degrees of Foot Angle Beat a Convincing Fake for Arthritic Knees
Personalized foot-angle retraining cut knee arthritis pain 1.2 points more than a sham program over a year, and an MRI marker of cartilage health held up better. Taxpayers paid for it, and there is nothing to refill.
Autoimmune & InflammationA Lupus Drug 'Failed' Its Trial. Its Patients Got Better Anyway.
Enpatoran missed its primary endpoint in 354 lupus patients. But disease activity dropped, the interferon signature fell, and the rashes cleared. The trial's model was built to catch a climbing dose-response, and the drug's effect had plateaued.
Autoimmune & InflammationPesticides Outlawed in the 1970s Are Still in Women's Blood, and They Track With Chronic Inflammation
French scientists screened 45 banned or barely-regulated chemicals in 468 women's blood. Two pesticides cancelled decades ago still tracked with elevated inflammation, and the PFAS quietly pushed an immune signal down.
Autoimmune & InflammationThe Cell Long Dismissed as Brain 'Glue' Is Presenting Your Nerves to the Immune System
For a century, astrocytes were dismissed as the brain's passive scaffolding. Now researchers have caught them inside multiple sclerosis lesions dressed as immune cells, arming the very T cells that attack the brain.
Autoimmune & Inflammationargenx's Own Scientists Found Antibody Levels Alone Don't Explain Who Its $225,000 Myasthenia Drug Helps
Six of the paper's authors work for argenx and hold its stock. Their data on 50 patients shows efgartigimod's benefit tracked more closely with how thoroughly it disarmed the rogue antibodies than with how many it stripped away.
Autoimmune & InflammationThe Air Never Arrives One Pollutant at a Time, but the Rules Pretend It Does
In a big European analysis, almost every pollutant tested on its own came back borderline. Measure the whole mixture the way it actually reaches the lung, and the adult-asthma signal shows up.
Autoimmune & InflammationThe 47th Human Blood Group Was Hiding in a Protein Almost Too Small to Find
More than 99.9% of us carry the AnWj antigen without knowing. For the rare few born without it, a routine transfusion can turn dangerous, and until now no genetic test could reliably identify them before the damage was done.
Autoimmune & InflammationSeven Biologics, Up to $47,000 a Year, and 89 Percent of Europe's Severe Asthmatics Still Aren't in Remission
The Lancet calls severe asthma an 'unmet need.' A 13,455-patient European registry shows most of those patients are already on the pricey biologics, and 89 percent still have active disease.
Autoimmune & InflammationDonor T Cells Cross Into the Gut Lining and Become Resident Killers That Won't Leave
Columbia researchers tracked more than 51,000 donor T-cell clones across two years and found the ones tied to the worst graft-versus-host disease change identity depending on where they land in the gut, and spike in the blood weeks before symptoms show.
Autoimmune & InflammationA Fat 'Brake' Eased Pain in 49 Men but Barely Touched the Swelling
UCL researchers gave 49 healthy men a drug GlaxoSmithKline shelved after early trials. Pain resolved faster and a class of immune cells shrank, but the heat, redness, and swelling showed no significant change.
Autoimmune & InflammationOxford Found the Cells That May Mark Which Joints Rheumatoid Arthritis Attacks. They Were There Before You Were Born.
The joints rheumatoid arthritis attacks and the ones it spares are built differently in the womb, seeded with different cells before a single joint ever swells.
Autoimmune & InflammationThe Immune Cells That Calm Autoimmune Disease Can Also Ignite It. One Protein May Hold the Switch.
Regulatory T cells keep autoimmune disease in check, but under inflammation they can shed their identity and turn inflammatory. In mice, researchers find a protein called TIF1γ restrains that defection by sending a runaway growth signal to be destroyed.
Autoimmune & InflammationMicrofold Cells Got Filed as the Gut's Mail Slot. They Were Organizing Its Defense.
The specialized cells that hand your gut bacteria to the immune system turn out to build the niche that keeps antimicrobial defense switched on, and the same signal that makes them wires in the brake.
Autoimmune & InflammationThe Gut's Doorway Cells Have a Second Job: Landlord to Its Barrier Defenders
Microfold cells were filed away as passive antigen samplers. In mice, they turn out to build and staff the niche that keeps the gut's IL-22 defenders alive, the cytokine that fortifies the intestinal barrier and keeps sampled bacteria contained inside its immune outposts.
Autoimmune & InflammationThey Worried a Pig Kidney Would Burn the Bridge to a Human One. In the First Two Patients, It Didn't.
A gene-edited pig kidney kept Tim Andrews off dialysis for a record 271 days before it failed and came out. The worry was that it would leave his immune system too sensitized for a human match. In the first two patients, it hasn't.