drug-repurposing
3 stories tagged "drug-repurposing"
Cancer
UC Irvine's 'Framework' for Safer CAR-T Is a Hypothesis Essay, Not a Study
The senior author consults for Kite Pharma, whose Yescarta accounted for all 6 grade-5 neurotoxicity deaths in the cited review's real-world data, the exact harm the paper proposes to treat.
Drugs & FDAThe FDA Pulled Infigratinib as a Cancer Drug in 2024. It Just Passed Phase 3 in Children With Dwarfism.
The FDA pulled infigratinib as a failed cancer drug in 2024. Now its maker says the same pill grows children with dwarfism faster, on a surrogate no one has yet shown reaches adulthood.
CancerFibrolamellar Carcinoma Hides Immune Cells in Scar Tissue. A Drug Approved in 2008 Pulled Them Back Out.
Fibrolamellar carcinoma mostly kills young adults, and checkpoint immunotherapy bounces off it. Researchers found the tumor herds T cells into fibrous bands, and a drug shelved for stem-cell work since 2008 freed them in patient tissue. No human trial has started.