Thursday, October 29, 2026 Evidence-led medical research news
The First Cohort
Medical research, with the receipts

vaccines

20 stories tagged "vaccines"

Infectious Disease

The Hepatitis B Shot America Calls Essential on Day One: Ontario Gives It in Grade 7

Ontario's routine hepatitis B program starts in grade 7, and Canada reported four acute cases in children under 15 in 2021. In the U.S., a court order keeps the universal shot in the first hours of life.

Investigations

The Mucosal Immunologist His Own University Declared No COVID Expert

Robert Clancy spent his career on the airway immunity a shot in the arm was never built to raise. When the transmission promise collapsed, Newcastle had already ruled him no COVID expert.

Investigations

The 33 Infections the CDC's 90 Percent Vaccine Number Left Out

In March 2021 the CDC announced that mRNA vaccines cut infection risk by 90 percent. Its own report set aside 33 infections that struck in the days after the shot, and a peer-reviewed critique shows how that counting rule can make a useless vaccine look 48 percent effective.

Drugs & FDA

Trump's FDA Nominee Backed Cutting the Vaccine Schedule, Then Hid Behind 'Safe and Effective' Under Oath

Heidi Overton stood beside Trump as he cut the childhood vaccine schedule from 18 diseases to 11. At her confirmation hearing she spent two hours calling every FDA-approved vaccine 'safe and effective' and refused to defend the reform she coordinated.

Investigations

The Ebola Vaccine 2,000 Congolese Frontline Workers Received Isn't Known to Work on the Strain Killing Them

Bundibugyo Ebola has no licensed vaccine, so the response is dosing frontline workers with Ervebo, approved only against a different strain, while the State Department fast-tracks $50 million to CEPI and a four-candidate portfolio that includes Moderna, in an outbreak the surveillance system missed

Infectious Disease

A 2014 Trial Warned That Correcting Vaccine Fears Backfires on the Hesitant. Public Health Corrected Harder.

A randomized trial found that correcting MMR-autism fears left the most hesitant parents less likely to vaccinate. A decade later, a panel of credentialed doctors in Sydney shows the trust cost of correcting harder anyway.

Investigations

Kennedy Reopens the Federal Vaccine Rulebook, Starting With the Words That Decide Which Shots Your Child Gets

HHS is asking whether the three labels that decide which shots your child gets still work, and putting the COVID-era override of its own vaccine advisers on the record as the reason public trust cracked.

Infectious Disease

Arizona State's AI Flags Healthy People as 'Weak' Vaccine Responders Without Reporting How Often It's Right

Arizona State's AI sorts roughly one in twenty healthy people into the 'weak responder' column. The clinical payoff, in the lead author's own words, is more doses. Nobody reported how often the model is right.

Infectious Disease

Kindergarten Vaccine Exemptions Doubled in Five Years. The Number Is a Verdict on the Agencies, Not the Parents.

Exemptions climbed to a record 4.2 percent of kindergartners while medical exemptions never budged from 0.2 percent. The rise is not a medical event. It is five years of institutional credibility spent, showing up in the one column parents control.

Infectious Disease

The Licensed Ebola Vaccine Was Never Proven to Stop the Strain Now Killing Congo

Bundibugyo virus has driven the fastest-growing Ebola outbreak on record, with 1,707 deaths across eastern Congo and nearly 90 percent of cases in Ituri, and the WHO's own experts say the one licensed Ebola vaccine should not be used against it.

Infectious Disease

The Same System Now Racing to Test a Bundibugyo Ebola Vaccine Had Nineteen Years to Build One

Bundibugyo Ebola was identified in 2007. By the time this year's outbreak passed 1,200 cases there was still no licensed vaccine and none in clinical development. Now roughly $75 million is moving to test three experimental shots on the people dying from it.

Infectious Disease

The Ebola Vaccine We Celebrated Doesn't Touch the Strain Now Burning Through Congo

Congo's Ebola outbreak has passed 1,000 cases and is rising faster than any before it, but it is caused by Bundibugyo virus, against which the licensed Ebola vaccine and antibody drugs were never designed to work.

Infectious Disease

Decades of Failed Diarrhea Vaccines Kept Hitting the Wrong Coat. A WashU Team Just Found the Scissors Underneath.

A WashU-led team identified a structurally conserved patch on three mucus-cleaving enzymes that ETEC, Shigella, and other gut pathogens all use to breach the intestinal barrier, offering a single antibody target the field has chased for decades.

Infectious Disease

The textbook said B cells take turns. A new temporal map of a malaria infection says they don't.

A new Nature Immunology temporal map of B cell responses to malaria in mice catches class-switching, clonal expansion, and somatic hypermutation overlapping from the first week, scrambling the tidy stepwise story textbooks still teach.

Brain & Aging

The Shingles Vaccine Keeps Cutting Dementia Risk. The Reason May Not Be the Shingles.

Four big studies now tie the shingles vaccine to lower dementia risk. The most useful finding is that the same effect shows up with an RSV vaccine that shares its adjuvant.

Investigations

Aaron Siri Wrote a Book Made of Court Filings

A new book by attorney Aaron Siri assembles a decade of FOIA wins, court filings, and depositions into one record of what the federal vaccine docket does and does not say.

Drugs & FDA

A Fentanyl Vaccine for Mice. An Overdose Decline for Humans.

Scripps Research published a clever chemistry redesign that let mice's immune systems recognize an entire class of fentanyl analogues. The headlines called it an overdose blocker. The mice are doing fine. Humans are years away, and the overdose decline is already happening without it.

Drugs & FDA

A DoD-Funded Fentanyl Vaccine Is Headed to Phase 1. Antibodies Don't Stop a Supply Chain.

A Pentagon-funded fentanyl vaccine licensed to startup ARMR Sciences will begin Phase 1 in the Netherlands in early 2026. Three decades of failed addiction vaccines, and a supply chain that runs through Chinese precursor labs, are the context the press release leaves out.

Infectious Disease

The AI Vaccine That 'Passed' Its First Trial Three Years Ago

Cambridge finished the Phase 1 trial in 2023. The press tour arrived in 2026. The paper, when you read it, said the immunogenicity was modest.

Investigations

Doctor Mike Plays 'Never Have I Ever' With a Firefighter. Watch What's Around the Bit.

Doctor Mike's lighthearted Never Have I Ever video sits at the top of a funnel that includes a $997 media academy, a UNICEF vaccine-ambassador title, and an ongoing pitch to pharmaceutical executives about social-media trust.