Autoimmune & Inflammation Why Anti-TNF Keeps Failing So Many Crohn's Patients: The Drug Never Reached the Cell Holding the Disease Open
Anti-TNF biologics have muzzled the immune system for 25 years, and up to 46 percent of Crohn's patients still fail them. A single-cell atlas points at the structural cells of the gut wall, epigenetically rewired into a state the drugs were never built to reach.
By Sarah Okonkwo · August 13, 2026