infectious-disease
7 stories tagged "infectious-disease"
The Nose-Spray TB Vaccine in Your Feed This Week Has Only Ever Worked in Mice
Johns Hopkins fused two genes into a nasal spray, added it to a drug cocktail, and cleared tuberculosis faster in mice. DNA vaccines have dazzled mice for thirty years and disappointed humans nearly every time. This one has not been in a person yet.
Infectious DiseaseThe Gut Lining Starves Salmonella of Iron, a Trick We Thought Only Immune Cells Knew
Salmonella sickens more than a million Americans a year. University of Vermont researchers found the cells it invades fight back by withholding the iron and manganese the bacteria need, a defense the textbooks credited mainly to immune cells.
Infectious DiseaseMost of These Ebola Patients Aren't Bleeding. That's Why It's Spreading.
A Bundibugyo virus outbreak in DRC and Uganda has topped 1,100 confirmed cases, yet roughly nine in ten patients show no bleeding, the symptom everyone is trained to look for.
Infectious DiseaseMost People's Bodies Quietly Beat TB. The Ones Who Lose Are Drowning Their Own T Cells.
A new single-cell study of the airways of TB-exposed people finds that progression to disease tracks with a neutrophil flood that smothers protective T cells, with type I interferon as the switch.
Infectious DiseaseDecades of Failed Diarrhea Vaccines Kept Hitting the Wrong Coat. A WashU Team Just Found the Scissors Underneath.
A WashU-led team identified a structurally conserved patch on three mucus-cleaving enzymes that ETEC, Shigella, and other gut pathogens all use to breach the intestinal barrier, offering a single antibody target the field has chased for decades.
Infectious DiseaseThe cheaper staph antibiotic just won the biggest trial ever run
The largest randomized trial ever run for staph bloodstream infection finds the cheap generic antibiotic cefazolin works as well as the older standard, with less kidney damage and no pharma money behind the answer.
Infectious DiseaseAmerica's Ebola Fortress: History Has Tested This Strategy, and It Failed
Washington has built a wall around the Ebola outbreak in Central Africa. The last time America tried this, the evidence says the wall leaked, and so did the response.