mc4r

A Brain Protein Made Female Mice Overeat Fat, and the $441,000 Obesity Drug Worked Weakest on Them

Dietary fat switches on an appetite-protecting brain protein in male mice but not females. Delete it and the females overeat fat, gain more weight, and setmelanotide, the $441,000-a-year MC4R obesity drug, loses much of its appetite-suppressing punch on them.