orexin
2 stories tagged "orexin"
Drugs & FDA
Takeda Fixed the Narcolepsy Drug That Was Poisoning Livers. Now You Can't Buy It.
Oveporexton is the first drug to replace the orexin signal narcolepsy destroys, instead of stimulating around a tired brain. At the higher dose it leaves 60 percent of patients newly insomniac, and it still has to clear DEA scheduling before it reaches a pharmacy shelf.
Drugs & FDAThe FDA Approved Narcolepsy's First Orexin Agonist. Takeda's Last One Was Pulled for Liver Injury.
Takeda's oveporexton switches on the orexin receptor that narcolepsy type 1 patients can no longer signal. The company's last orexin drug was halted in 2021 after patients crossed serious liver-injury thresholds.