clonal-hematopoiesis
3 stories tagged "clonal-hematopoiesis"
Autoimmune & Inflammation
The Rogue Clones in Aging Blood Shrug Off the Inflammation That Wears Down Their Neighbors
By 70, more than half of people carry mutant blood-stem-cell clones on sensitive tests. Marrow maps show them living amid inflamed, fibroblast-rich pockets, and the mutants barely flinch at the inflammation.
CancerThe Marrow Around a Common Aging Blood Clone Is Already Inflamed and Starting to Scar
Clonal hematopoiesis turns up in 10 to 20 percent of adults over 60, and the blame has always landed on the mutant cell. Single-cell maps of living marrow show the tissue around it inflamed and laying down scar before any cancer appears, which suggests the clone is not acting alone.
Brain & AgingThe Same Mutations That Drive Blood Cancer Keep Turning Up in Alzheimer's Brains
A new Cell paper finds Alzheimer's brains are riddled with the same mutations that drive blood cancers, in the immune cells that are supposed to be protecting neurons.