Sunday, June 14, 2026 Evidence-led medical research news
The First Cohort
Medical research, with the receipts

addiction

3 stories tagged "addiction"

Drugs & FDA

A DoD-Funded Fentanyl Vaccine Is Headed to Phase 1. Antibodies Don't Stop a Supply Chain.

A Pentagon-funded fentanyl vaccine licensed to startup ARMR Sciences will begin Phase 1 in the Netherlands in early 2026. Three decades of failed addiction vaccines, and a supply chain that runs through Chinese precursor labs, are the context the press release leaves out.

Brain & Aging

Disappointment, Not Reward, Is What Breaks a Habit. Half of Older Adults Are on Drugs That Blunt Acetylcholine.

An OIST team caught the mouse brain firing acetylcholine the moment an expected reward failed to land. That surge is what lets the animal switch strategy. Close to half of community-dwelling older adults are on drugs that block the same receptors.

Metabolic & Weight

A gut hormone keeps showing up in the brain's reward circuit, and 600,000 veterans just gave us the biggest hint yet that it matters

A VA cohort of 606,000 diabetic veterans on GLP-1 drugs showed lower risks of new substance use disorders and large drops in overdose and drug-related death versus a peer diabetes drug. The mechanism story is where it gets interesting.