Sunday, June 14, 2026 Evidence-led medical research news
The First Cohort
Medical research, with the receipts

pharma

4 stories tagged "pharma"

Drugs & FDA

Medicare's Product-Hopping Loophole Is Back On The Chopping Block. The Bigger Pharma Giveaway Isn't.

The Trump administration on Thursday proposed closing the product-hopping loophole that lets drugmakers reset Medicare's negotiation clock by tweaking inactive ingredients. It is the same fix the same administration quietly tabled in October.

Cancer

Ozempic's 30 Percent Breast-Cancer Headline, and the Trial Evidence It Walked Past

A single-system observational study at ASCO 2026 attached a roughly 30% lower breast-cancer rate to GLP-1 use. The randomized record already on the table is quieter.

Metabolic & Weight

A gut hormone keeps showing up in the brain's reward circuit, and 600,000 veterans just gave us the biggest hint yet that it matters

A VA cohort of 606,000 diabetic veterans on GLP-1 drugs showed lower risks of new substance use disorders and large drops in overdose and drug-related death versus a peer diabetes drug. The mechanism story is where it gets interesting.

Drugs & FDA

Alnylam Bet $2 Billion on AI-Designed RNAi. The Check It Actually Wrote Was $30 Million.

Alnylam paid Inceptive Nucleics $30 million up front, with up to $2 billion in milestones tied to outcomes the rest of AI drug discovery has spent a decade failing to deliver.