cognitive-decline
11 stories tagged "cognitive-decline"
The Amino Acid That Sharpened Old Mice's Memory Made Neuron Loss Worse in Alzheimer's Mice
D-serine improved memory in old mice in a 2023 study now recirculating as news. Given to Alzheimer's model mice, the same amino acid made neuron loss worse, and the human trial behind the hype was a single dose.
Brain & AgingThe MIND Diet's '2.5 Younger Brain-Years' Meet the Trial That Couldn't Find Them
Framingham brain scans linked closer MIND-diet adherence to grey matter aging about 2.5 years slower. A 604-person randomized trial that put older adults on the diet for three years found no edge over a control diet.
Brain & AgingIn Aging Brains, Thicker Myelin Showed Up Where Thinking Fell Fastest
In brain tissue from a subset of 866 Scots tested from age 70 to 82, the fastest decliners had smaller nerve fibers, thicker myelin and fewer myelin-making cells carrying the stress protein NRF2.
Brain & AgingD-Serine Helped Old Mice in the Maze and Did Nothing for Their Skin or Bones
Restoring the protein menin in one patch of hypothalamus gave 20-month-old mice thicker skin, more bone and better learning. D-serine, the amino acid now in the headline, improved only the learning, and the one trial in healthy older adults that both news stories cite gave each person a single dose
Brain & AgingA Salsa Class, a Grocery List, and 38 Check-Ins Beat Health Advice on Memory by 55%
Across 11 Latin American countries, a coached program of exercise, an adapted MIND diet, and cognitive training improved older adults' thinking 55 percent more than periodic health advice, with no infusion chair and no $26,500-a-year drug.
Brain & AgingAny Amount of Midlife Movement Tracked With Slower Brain Decline, Most Clearly in Mexican American Adults
In a San Antonio cohort followed since 1979, any physical activity in midlife tracked with slower brain decline, and the link showed up most clearly in the Mexican American adults Alzheimer's research keeps leaving out.
Brain & AgingSame Diet, Same 15 Pounds: Only the Women Who Ate in an 8-Hour Window Got Sharper
Two groups of older women cut the same calories and lost the same 15 pounds over six months. The ones who packed eating into an 8-hour window still scored better on problem-solving, from a 47-person pilot that hasn't been peer-reviewed.
Brain & AgingThe Sweeteners Sold to Diabetics as the Safe Swap Tracked With Faster Brain Aging
Brazilian researchers followed 12,772 adults for eight years. The ones consuming the most artificial sweeteners, about a diet soda's worth a day, showed cognitive decline equal to 1.6 extra years of brain aging, and diabetics fared worst.
Brain & AgingIn Mice, Early Stress-Drinking Corroded a Brain Region a Long Sobriety Couldn't Repair
In mice, pairing alcohol with stress in early adulthood damaged a tiny noradrenaline hub in the brainstem, and a prolonged stretch of abstinence didn't reverse it. The cognitive cost surfaced in middle age.
Brain & AgingMiddle-aged Americans Are Weaker, Lonelier, and Forgetting More Than Their Parents Did at the Same Age
A 17-country study finds U.S. adults in their 50s are doing worse on memory, grip strength, loneliness, and depression than their parents were. The United States is the only country going meaningfully backward.
Nutrition & Food8,300 Brazilian elders, one saltshaker, and the 80 percent of sodium nobody mentions
A Frontiers in Public Health survey of 8,336 Brazilians over 60 found older men reach for the saltshaker most. Buried in the same paper: the shaker only accounts for 6 to 20 percent of total sodium. The other 70-plus percent already arrived from the factory.