cancer
65 stories tagged "cancer"
Norway's Own Screening Adviser Ran the Numbers: About One in 86 Screened Women Overdiagnosed
By its own adviser's estimate, Norway's mammography program overdiagnoses about one in 86 screened women, roughly three for every breast cancer death it prevents, while a 58-trial review finds early detection is no reliable stand-in for fewer deaths.
CancerRoche's KRAS Pill Beat the Older Drugs on Survival, an Endpoint Lumakras Never Won Against Chemotherapy
Median survival ran 17.7 months on divarasib and 12.0 on a control arm that was nine-tenths Lumakras, a drug whose own confirmatory trial showed no survival edge over chemotherapy.
Nutrition & FoodOf 28 Links Between Everyday Drinks and Mouth Bacteria, Alcohol Claimed 25
A federal study of 5,598 Americans tied alcohol, mostly beer and liquor, to 25 of 28 links between drinks and mouth bacteria. It landed months after the Dietary Guidelines dropped their daily drink limits.
CancerMayo's Pancreatic Cancer AI Also Flags One Cancer-Free Scan in Five
Mayo's REDMOD caught 73 percent of pancreatic cancers on CT scans taken months before diagnosis, nearly double the radiologists' rate. It also flagged about 19 percent of cancer-free scans, and its lead researcher says it has not been tested at deployment prevalence.
CancerCompass Plans to File a Biliary Cancer Drug Without the Survival Trial the FDA Asked For
Tovecimig plus chemotherapy shrank more biliary tract tumors than chemotherapy alone, but median survival was 8.9 months against 9.4, and 93.5 percent of the combination arm had grade 3 or worse adverse events. The FDA recommended a survival trial before filing. Compass plans to file anyway.
Nutrition & FoodCold Cuts and Breakfast Cereal Pulled Opposite Ways in a Giant Colon Cancer Study
In 461,682 Americans, total ultra-processed food showed no link to colorectal cancer. Inside the label, reconstituted meat products tracked with higher risk and packaged bread and cereal with lower, while a federal definition sits under White House review.
CancerThe Vitamin C Trial That Missed Its Goal and Counted 11 Deaths Against 24
Copenhagen and USC researchers gave 1,000 mg of plain vitamin C a day to people with pre-leukemic blood disorders. The mutant clones grew regardless, but over three years of follow-up 11 patients assigned to the vitamin died, against 24 assigned to placebo.
CancerThe Number Behind GSK's Rectal Cancer Approval Is 47 Percent, Not 76
Independent reviewers confirmed a year-long complete response in 54 of 116 AZUR-1 patients. GSK's release also carried an exploratory 76 percent. For a narrow slice of rectal cancer patients, the drug may still spare them radiation and surgery.
Drugs & FDAThe FDA Fast-Tracked GSK's Rectal Cancer Drug and Left the Trial's Own Scorecard Out of Its Announcement
Independent reviewers found 47 percent of evaluable AZUR-1 patients held a complete response for a year, the trial's registered endpoint. The FDA's announcement quoted friendlier measures instead.
InvestigationsOven Gloves Bought From a Top Online Retailer Tested 89 Percent Asbestos
A private citizen asked two Italian mineralogists whether a cheap pair of heat-resistant gloves labeled Made in China was asbestos. The lab answered 89 percent chrysotile by weight, and the listing never said so.
CancerTo Keep Cancer-Fighting Cells Alive, a Sloan Kettering Lab Wants Them to Fight Less Hard
Memorial Sloan Kettering researchers say throttling exhausted T cells with a drug class already used against melanoma may keep them alive longer. So far the evidence comes only from lab and animal models.
CancerThe Urine Test That Could Retire the Bladder Scope Already Has a Startup Behind It
Stanford's uRARE-seq caught 95 percent of localized bladder cancers in a case-control study and nearly tripled cytology's hit rate. It has not faced a prospective trial, and its lead author holds a stake in the spinout commercializing it.
Metabolic & WeightThe Leucine Trick That Boosts Your Mitochondria Also Shielded Lung Tumor Cells in the Lab
Leucine keeps cells from shredding the import docks on their mitochondria. In lab lung tumor lines rich in leucine's chemical family, the same biology came with resistance to a drug built to starve them.
CancerKetamine Failed Its Only Adequately Powered Cancer-Pain Trial, and Palliative Care Still Reaches for It
Ketamine's one adequately powered trial in advanced cancer pain found no benefit over placebo, more toxicity and worse quality of life. Fourteen years on, a 2026 review still tells clinicians to consider it.
CancerCat Breast Tumors Mirror Ours Genetically, and the Cure Talk Never Left the Dish
Almost 500 pet cats supplied tumors for the first large-scale map of feline cancer genes. Every claim about treating people still rests on cat tissue grown in a lab.
CancerMerck and Moderna Say Their Melanoma Vaccine Worked, but Two Months On the Public Still Hasn't Seen by How Much
Merck and Moderna have announced only that their phase 3 met its endpoints. The smaller trial behind the excitement missed the conventional two-sided significance bar, and one bank has modeled a price as high as $475,000 per patient.
Drugs & FDAFDA's Anktiva Approval for Papillary-Only Bladder Cancer Cites No Papillary-Only Patients
Seventeen months after refusing even to review ImmunityBio's application, the FDA expanded Anktiva's label by extrapolating from carcinoma in situ, and its announcement never mentioned the 80 papillary-only patients the company had actually studied.
CancerCancer Wasting Was Hiding in Two Million Routine Weigh-Ins
At Memorial Sloan Kettering, 48.8% of 59,493 tumor-sequenced cancer patients had at least one cachectic weight-loss episode over about five years. No drug is approved for it, and a French hospital coded it in under 1% of its cancer patients.
Drugs & FDATerence Tao Fears a Cancer Cure Nobody Can Explain. The FDA Clears Cancer Drugs That Never Proved They Extend Life.
Terence Tao says he would want a human expert to understand an AI cancer cure before taking it. The oncologist Vinay Prasad says that misses how medicine already works, and the receipts show the cancer drugs worth fearing are the legible ones approved on a shrinking tumor that never proved they help
Nutrition & FoodKeto Raised Tumor Counts in One Stretch of Mouse Gut and Cut Them in the Next, While the Ketones Sat It Out
In cancer-prone mice, a ketogenic diet meant more small-intestine tumors and fewer colon tumors, and the ketones long credited for keto's anticancer promise turned out to be bystanders.
Drugs & FDAGaming a Cancer Trial Is 'Cheap and Easy,' Says a Former Top FDA Official
Vinay Prasad says nobody needs AI to fake a phase 3 cancer win, and a Mayo Clinic audit found 16 of 96 FDA cancer approvals rested on control arms its authors judged suboptimal.
CancerThe 80.5 Percent Headline, and the Three Confirmed Responses Behind It
Vividion led its colorectal announcement with an 80.5 percent disease-control rate. In that same group, three tumors shrank enough to count as a response.
CancerThe Compound That Outsmarts Cancer's Defenses: Eight Cell Lines, a Few Mice, and a Startup
Baylor researchers say CS18 dismantles the survival switch tumors use to resist treatment. It works in eight cell lines and a handful of mice, and its inventors just incorporated a company around it.
CancerThe Healing Cells That Cheat Death Carry a Catch: Their Offspring Are Seven Times Harder to Kill
A radiation-blasted fruit fly rebuilt half its ruined tissue in two days, and the cells that pulled it off left descendants 7 times harder to kill, which may be close to how some tumors outlast the treatments meant to finish them.