genetics
5 stories tagged "genetics"
Lupus Hits Nine Women for Every Man, and the Reason May Be Hiding in DNA Both Sexes Share
Scientists sequenced more than 1.25 million immune cells and found over 1,000 genetic switches set differently in men and women, with the female side tuned for stronger inflammation. It may help explain why lupus hits nine women for every man.
Autoimmune & InflammationA Lung Atlas Found 1,000 Autoimmune-Risk Genes That Blood Studies Missed
For two decades, geneticists mapped thousands of autoimmune-risk variants that sat silent in blood cells. A 1.1-million-cell lung atlas shows the effects switch on only in immune cells lodged in tissue.
Autoimmune & InflammationA Map of 1.1 Million Lung Immune Cells Finds the Genetic Risk for Autoimmune Disease in Tissue, Not Blood
Researchers at La Jolla mapped genetic activity in 1.1 million lung immune cells and found about 1,000 genes whose activity is tuned by disease-risk variants only inside tissue, plus 1,700 that read differently in women than in men.
CancerThe Same Cancer Mutation, Opposite Effects: What 581 Mouse Tumors Say About Who Gets Sick
Cambridge and Yale gave four strains of mice one identical dose of a carcinogen. The tumors converged on the same pathway but took four different genetic routes to get there, and today's screening ignores the reason.
Autoimmune & InflammationThe Gene That Decides Whether Smoggy Air Wrecks Your Lungs
A University of Pittsburgh study of nearly 1,000 asthma patients pinpoints seven oxidative-stress genes that decide how badly dirty air damages the lungs.