Sunday, August 23, 2026 Evidence-led medical research news
The First Cohort
Medical research, with the receipts

weight-loss

6 stories tagged "weight-loss"

Metabolic & Weight

The Exercise Paradox: Lousy for Losing Weight, Your Best Bet for Keeping It Off

A study of more than 1,100 people found activity did almost nothing for the pounds they shed, yet it was one of the strongest signals of whether that weight stayed gone.

Metabolic & Weight

The Peptide Boom Hides One Divide: Human Trials on a Few, Rodent Data and Case Reports on the Rest

Semaglutide and tirzepatide erased up to 22 percent of body weight in trials with thousands of patients. The research-only peptides sold beside them, like BPC-157, have not completed a single published human efficacy trial. A popular 2026 guide lists them as equals.

Nutrition & Food

The NIH Weighed Every Meal to a Tenth of a Gram. Four AI Calorie Apps Undercounted by up to 345.

In a locked NIH metabolic kitchen where every ingredient was weighed to 0.1 grams, MyFitnessPal, Lose It!, CalAI, and Appediet each read a plate and undercounted it by a quarter to a third, missing the fat most of all.

Metabolic & Weight

The GLP-1s That Barely Move the Scale Don't Cause Hair Loss, and That's the Clue Everyone Missed

Women on semaglutide shed hair at about twice the rate of men, and the weakest GLP-1s show almost no signal, which points the cause away from the follicle and straight at how fast the weight comes off.

Metabolic & Weight

Both Groups Lost the Same Seven Kilos. Only the Calorie Counters Had to White-Knuckle It.

In an 18-month Adelaide trial, fasting and daily calorie-cutting stripped off the same seven kilos, but for the counters part of that loss ran on constant conscious restraint the fasters' scores never showed.

Metabolic & Weight

Switch Off One Protein Called Mitch, and Cells Start Eating Their Own Fat

Women with obesity carry more of it. Disable it in mice and they turn lean and muscular at once, the opposite of what the injectable weight-loss drugs do to your body.