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The First Cohort
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Brain & Aging

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Brain & Aging

In Mice, Early Stress-Drinking Corroded a Brain Region a Long Sobriety Couldn't Repair

In mice, pairing alcohol with stress in early adulthood damaged a tiny noradrenaline hub in the brainstem, and a prolonged stretch of abstinence didn't reverse it. The cognitive cost surfaced in middle age.

Brain & Aging

Longevity Clinics Sell Growth Hormone by the Vial. In Deep Sleep, Your Brain Makes It Free.

The muscle-building, fat-burning hormone that anti-aging clinics inject at a premium is the same one your hypothalamus releases every night you reach deep sleep. Berkeley mapped how, in mice, and the headline is already running ahead of the biology.

Brain & Aging

A Michigan Lab Grew a Living Skull Joint That Wouldn't Fuse. In Mice, It Held.

Craniosynostosis surgery reopens a fused infant skull; in some of the hardest cases it fuses right back and the child goes under the knife again. A triphasic scaffold kept the joint open in mice.

Brain & Aging

The Box-and-Banana Test Was Built for Apes. A Bumble Bee Worked It Out on Its Own.

Researchers in Finland trained bumble bees on two unrelated facts, a flower with sugar and a ball that rolls. With the flower moved out of reach, the bees combined the two into a solution nobody had shown them, on a task built for apes.

Brain & Aging

For Decades They Treated This Stroke Like a Clog. The Arteries Were Actually Too Wide.

People with widened brain arteries were four times more likely to have had a lacunar stroke, the type doctors have treated for decades as if it were a clog.

Brain & Aging

Alzheimer's Hitches a Ride on a Virus Your Neurons Tamed for Memory

In mice and in human Alzheimer's brains, toxic tau rides a protein called Arc, a virus your neurons domesticated for memory, from sick cells into healthy ones. Delete Arc and the spread nearly stops.

Brain & Aging

A Juice Company Built a Department Inside a Japanese University. Its Scientists Just Found Vitamin C Guards the Aging Brain.

Kagome, Japan's largest vegetable-juice maker, funded the work, employs two of its authors, and measured the vitamin itself. The gray-matter correlation it reported is real, and small enough to miss.

Brain & Aging

Senescence Built Your Hands Before It Ever Aged Your Skin

Cellular senescence, the process blamed for aging and disease, is also how an embryo sculpts fingers and clears its own tissue. That double life scrambles the anti-aging industry's tidy 'kill the zombie cells' pitch.

Brain & Aging

Lead Strips Dopamine From the Exact Brain Circuit ADHD Drugs Are Built to Rescue

Childhood lead keeps landing on the same target: the striatal dopamine circuit that ADHD drugs are built to rescue. A Philadelphia cohort just tied it to real diagnoses, not test scores.

Brain & Aging

Group Mindfulness Beat Standard Back-Pain Care for a Full Year, No Prescription Required

Boston researchers taught 451 patients to work with their pain instead of medicating it, and the gains outlasted the program. The university's press release skipped the part where the edge over usual care fell short of the bar the team set for itself.

Brain & Aging

A Federally Backed Trial Got High-Dose Fish Oil Into the Brain Fluid. The Memory Scores Never Moved.

DHA in the spinal fluid climbed 17 percent. Cognitive scores rose 2.76 points on fish oil, 2.67 on placebo. Two years of high-dose pills bought a rounding error.

Brain & Aging

A Federal Court Put This Pesticide Back on Your Food. UCLA Just Showed It More Than Doubles Parkinson's Risk.

Chlorpyrifos was pulled from American homes in 2001 and ordered off food crops in 2021. A manufacturer sued, won, and it's back on apples and strawberries while the science against it gets stronger.

Brain & Aging

Your Brain Has 170 Billion Cells and No Blueprint. Here's How One Cell Pulls It Off.

For fifty years the textbook said chemical gradients tell brain cells where to go. A new model says cells inherit their address from their family tree instead.

Brain & Aging

They Told Older Adults the Pill Was Fake. Their Memory Got Better Anyway.

A 90-person Italian trial gave older adults inert pills and told one group flat-out they were fake. That group improved as much as the deceived one. Here is what that does and doesn't prove.

Brain & Aging

Your Brain Files Speech Where You'd Least Expect: In Hearing and Touch, Not the Motor Cortex

A TMS study from McGill and Yale finds that newly learned speech is stored in the brain's hearing and touch regions, not the motor cortex long assumed to run the show.

Brain & Aging

The Alzheimer's Field Spent Decades Trying to Destroy These Droplets. A Baylor Lab Says the Droplets Were Never the Problem.

A Baylor lab reports that tubulin redirects Tau and alpha-synuclein away from toxic clumping in the test tube. It is elegant mechanism work, and not yet a drug, an animal, or a person.

Brain & Aging

The Brain Was Starving Before the Plaques Showed Up: Alzheimer's Metabolic Reframe Has a Case, Not a Trial

A rising camp says failing mitochondria, not amyloid plaques, may drive Alzheimer's first. The biology is compelling and the amyloid monoculture earned its reckoning, but the metabolic side has its own retractions and not one human trial showing it works.

Brain & Aging

Utah's Quiet Bet Against the Number-One Killer of New Mothers

Utah is scaling a free, CBT- and mindfulness-based perinatal depression pathway through MyChart in a state where suicide is the leading cause of maternal death.

Brain & Aging

Ultra-Processed Food Is Quietly Taxing Your Attention. The Mediterranean Salad Next to It Won't Pay the Bill.

A new Monash-led study finds ultra-processed foods track with worse attention and a higher dementia-risk score even after adjusting for Mediterranean diet quality. The biology of why is more interesting than the headlines admit.

Brain & Aging

Twelve Genes, One Overlooked Neuron, and the Rett Brain That Was Already Off Course

A Baylor team's single-cell map of female Rett mice finds 12 dysregulated genes and a previously unsuspected vulnerable interneuron, weeks before any symptom appears.

Brain & Aging

The Supervised Prehab Worked. The Home Version Hospitals Want to Sell You Did Not.

Two randomized trials in older surgical patients, one positive and one null, draw the same line under what "prehabilitation" actually requires, and why the version a hospital can hand you on paper did nothing.

Brain & Aging

The amyloid-versus-tau war in Alzheimer's might be the wrong fight

A four-person UC Riverside chemistry group argues amyloid beta and tau compete for the same microtubule binding sites, a unifying mechanism that cuts under Alzheimer's research's three-decade amyloid-versus-tau fight.

Brain & Aging

A 14-Patient Hand-Exoskeleton Study Lands in Science Advances, With a Headline That Outruns the Data

A Vienna-led team published a 14-patient feasibility study of a wearable hand exoskeleton with closed-loop electrical stimulation. The mechanism is genuinely novel; the headline is doing work the data cannot.

Brain & Aging

Magic Mushrooms and an 80-Year-Old's Memory: What the Hype Actually Has, and What It Doesn't

An 80-something woman with advanced Alzheimer's took five grams of mushrooms and started speaking again. The biology behind why that might happen is real. The trial base it rests on is thinner than the headlines admit.