Sarah Okonkwo
270 stories · Page 4 of 12
Fused Into One Cell, a Neutrophil and a Macrophage Ate Tumors Two Ways
CAR-macrophage therapy keeps stalling in solid tumors: it can't get in, and it can't finish. Fuse a neutrophil onto it and, in mice, one dose shrank the tumor and kept it from coming back.
Brain & AgingA Salsa Class, a Grocery List, and 38 Check-Ins Beat Health Advice on Memory by 55%
Across 11 Latin American countries, a coached program of exercise, an adapted MIND diet, and cognitive training improved older adults' thinking 55 percent more than periodic health advice, with no infusion chair and no $26,500-a-year drug.
Autoimmune & InflammationOxford Found the Cells That May Mark Which Joints Rheumatoid Arthritis Attacks. They Were There Before You Were Born.
The joints rheumatoid arthritis attacks and the ones it spares are built differently in the womb, seeded with different cells before a single joint ever swells.
Brain & AgingDirty Air Is Linked to 16 Percent More Inflammation in Your Blood. Does That Damage Reach Your Brain?
Each step up in long-term fine-particle exposure is tied to nearly 16 percent higher inflammation in older adults' blood, and a CHARLS analysis asks whether that same signal is what wears down the aging brain.
Brain & AgingAutistic Teenagers Are Bullied Three Times as Often, and We Have Barely Studied How to Protect Them
Autistic teenagers are bullied roughly three times as often as their peers, and the sexual-victimization risk that shadows them into adulthood is just as real, yet the research meant to protect them is small, scattered, and looking the other way.
Metabolic & WeightAt the Dose the FDA Calls Safe, Two Sweeteners Reshaped the Guts of Mouse Grandpups That Only Drank Water
Chilean researchers fed mice sucralose and stevia at the doses the FDA calls safe. The metabolic marks showed up in grandpups that only drank water.
Nutrition & FoodYour Gut Bacteria Decide Whether Sorbitol Is Harmless or a Liver Problem
Sorbitol was sold for decades as the inert, guilt-free sugar swap. In zebrafish stripped of their gut bacteria, WashU researchers watched the intestine's own sorbitol reach the liver and feed the same fructose-metabolism pathway that packs on liver fat.
Infectious DiseaseWeathered Plastic in the Water Grows Its Own City of Drug-Resistant Bacteria
On weathered plastic drifting from a lake into a river, researchers logged 102 new antibiotic-resistance gene subtypes moving into the surrounding water in five weeks.
Brain & AgingThe Amino Acid Sold for Focus Tracked Fewer Years for Men, Not Women
In more than 270,000 people, men with higher blood tyrosine died sooner, by nearly a year on the genetic estimate. Women showed no clear lifespan signal. The amino acid is sold in capsules for focus.
Metabolic & WeightEurope Wants Every Heart Patient Tested for Kidney Disease. The Test Is Cheap. The Drugs It Funnels You Toward Are Not.
The European Society of Cardiology now says screen every heart patient for kidney damage and start the drugs early. More than 80 percent of the guideline's authors report financial ties to industry.
Brain & AgingThey Didn't Rewrite the Memory. A Flinch of Surprise Predicted Who Got Better.
Polish researchers had 180 young adults imagine a defender stepping into a painful childhood memory. The rewrite itself helped only modestly. What predicted who improved was an involuntary jolt of surprise, measured in the skin, when the expected blow never came.
Autoimmune & InflammationThe Immune Cells That Calm Autoimmune Disease Can Also Ignite It. One Protein May Hold the Switch.
Regulatory T cells keep autoimmune disease in check, but under inflammation they can shed their identity and turn inflammatory. In mice, researchers find a protein called TIF1γ restrains that defection by sending a runaway growth signal to be destroyed.
Infectious DiseaseThe HIV Reservoir Everyone Called Untouchable Has Natural Killer Cell Fingerprints All Over It
In 104 people on long-term HIV treatment, the ones whose natural killer cells were armed a certain way carried far fewer intact copies of the virus. The reservoir that defeats every cure turns out to carry the fingerprints of an immune fight nobody thought was happening.
Brain & AgingThe Calm-Down Breath That Made People Bet Bigger
A 2-second inhale and an 8-second exhale slowed 41 people's hearts and, across the same sessions, made them more willing to take the risky bet. The pull came from the reward side, not from any loss of caution.
Autoimmune & InflammationMicrofold Cells Got Filed as the Gut's Mail Slot. They Were Organizing Its Defense.
The specialized cells that hand your gut bacteria to the immune system turn out to build the niche that keeps antimicrobial defense switched on, and the same signal that makes them wires in the brake.
Nutrition & FoodWhat Probiotics Actually Do for Autistic Kids Isn't What the Label Promises
A review pooling about 1,000 participants found the clearest probiotic effect in autistic children lands on the gut, not behavior. The supplement aisle sells the reverse.
Metabolic & WeightWhat Fluoride Does Once It Gets Past the Teeth
As Washington fights over whether to keep fluoridating tap water, the sharpest evidence on childhood fluoride and cardiovascular risk comes from places where the dose dwarfs anything out of a U.S. tap. The whole argument is about how much.
Autoimmune & InflammationThe Gut's Doorway Cells Have a Second Job: Landlord to Its Barrier Defenders
Microfold cells were filed away as passive antigen samplers. In mice, they turn out to build and staff the niche that keeps the gut's IL-22 defenders alive, the cytokine that fortifies the intestinal barrier and keeps sampled bacteria contained inside its immune outposts.
Metabolic & WeightThe Cheapest Measurement in the Exam Room Beat BMI and the Lancet's Four-Part Obesity Formula
BMI flagged 37 percent of the adults a body-fat scan called obese. On overall accuracy, a cloth tape around the waist caught far more and edged out the four-measurement framework built to fix BMI.
Metabolic & WeightYour Immune Cells Remember Obesity for Up to a Decade After the Weight Comes Off
CD4 T cells hold chemical marks of past obesity for an estimated five to ten years, which may help explain why the risk for diabetes and some cancers can linger long after the scale reads normal.
Autoimmune & InflammationThey Worried a Pig Kidney Would Burn the Bridge to a Human One. In the First Two Patients, It Didn't.
A gene-edited pig kidney kept Tim Andrews off dialysis for a record 271 days before it failed and came out. The worry was that it would leave his immune system too sensitized for a human match. In the first two patients, it hasn't.
Brain & AgingThe ADHD Creativity Bump Is Modest, and It Fades Right Where the Symptoms Turn Clinical
The headlines sell the wandering ADHD mind as a hidden creative gift. The data underneath shows the edge is modest and flattens right as symptoms cross into the clinical range.
Nutrition & FoodAll 719 Blood Samples Carried Mold Toxins, and the Youngest Children Carried the Riskiest Kidney Dose
Researchers tested the blood of 719 women and young children in rural Bangladesh. Ochratoxin A turned up in every single one, and modeling put up to 99 percent of the children over the line toxicologists use to flag a cancer-risk exposure.
Nutrition & FoodThe Coffee-Weakens-Bones Study Never Analyzed a Single Fracture
Nearly 10,000 older women, ten years of hip scans, and the coffee alarm that made headlines came from a spline curve that never cleared statistical significance.