alzheimers
23 stories tagged "alzheimers"
The Omega-3 Trial Headlined as a Brain-Health Bust Was Built to Measure Spinal Fluid
Two years of high-dose DHA reached the spinal fluid of older adults exactly as planned. The memory scores behind the "no benefit" headlines were an exploratory outcome, and 38 percent of volunteers dropped out.
Brain & AgingYour Aging Brain May Be Swapping Details for Wisdom. Nobody Has Measured the Wisdom.
Three neuroscientists argue that midlife forgetting is the brain shifting toward meaning. Older studies document the lost detail and the confident false memories that come with it. The promised wisdom has never been measured.
Brain & AgingClear Most of the Brain's Microglia and Alzheimer's Mice Sleep Two Hours More, Plaque Load Unchanged
In amyloid mice, plaque piled up while lost sleep held flat, and the sleep came back when most microglia were cleared. That is an awkward result for an industry selling plaque removal.
Brain & AgingDrugs Aimed at This Week's Brain-Inflammation Target Have Already Failed in Patients
AstraZeneca and Pfizer each took a P2X7 blocker into rheumatoid arthritis trials, and neither beat placebo. A Birmingham lab now says the same receptor could tame inflammation in Alzheimer's and Parkinson's.
Brain & AgingA Gut Molecule Tied to Diabetes and Clogged Arteries Now Tracks With Alzheimer's Decline
In 1,196 cognitively healthy adults, the people with the most of one gut-made molecule in their blood declined fastest, and a genetic variant carried by about 43 percent was linked to higher levels.
Brain & AgingIn Lab Tests, the Alzheimer's Fragment Labeled 'Non-Amyloidogenic' Builds Amyloid Faster Than Amyloid Beta
For decades the alpha pathway was billed as the safe way to cut the Alzheimer's precursor protein. Its leftover fragment, p3, builds fibrils in less than half the time amyloid beta needs in lab tests, forms ring-shaped pores, and turns up in plaques where a common antibody stain can't tell the two a
Brain & AgingAlzheimer's Drugmakers Bet on Raising This Brain Sugar. Glucosamine May Be Overfeeding It.
In UF Health records, people with mild cognitive impairment who took the joint supplement were 25 percent more likely to slip into dementia. Glucosamine feeds the same brain chemistry a failed Alzheimer's drug was built to raise.
Brain & AgingA Salsa Class, a Grocery List, and 38 Check-Ins Beat Health Advice on Memory by 55%
Across 11 Latin American countries, a coached program of exercise, an adapted MIND diet, and cognitive training improved older adults' thinking 55 percent more than periodic health advice, with no infusion chair and no $26,500-a-year drug.
Brain & AgingFor Twenty Years, Women Were Warned That Estrogen Raised Their Dementia Risk. Stanford's Autopsies Point the Other Way.
A randomized federal trial spent two decades warning that hormone therapy raised older women's dementia risk. A Stanford autopsy study just found the opposite association. The catch: both studied women who started the drug far too late to settle it.
Brain & AgingThe Fat Molecule That Rides From Your Waistline to Your Brain, and Feeds Alzheimer's Once It Gets There
In obese mice, a membrane fat called phosphatidylethanolamine packed into tiny vesicles, rode to the brain, and sabotaged the immune cells that clear amyloid. An investigational drug reversed it, in mice.
Brain & AgingAnti-Tau Alzheimer's Drugs Keep Hitting Their Target and Missing the Disease
Tau is the new headliner at the Alzheimer's conference, but the anti-tau antibodies keep proving they bind the protein while doing nothing for patients. The clearest win so far is a blood test.
Brain & AgingA Brain Full of Plaques and a Mind That Held: The Cells That May Explain Alzheimer's Resilient Third
About a third of people whose brains show the full pathology of Alzheimer's never develop dementia. Dutch researchers say the difference may not be how many young neurons they have, but whether those cells switch on a survival program instead of dying.
Brain & AgingAlzheimer's Hitches a Ride on a Virus Your Neurons Tamed for Memory
In mice and in human Alzheimer's brains, toxic tau rides a protein called Arc, a virus your neurons domesticated for memory, from sick cells into healthy ones. Delete Arc and the spread nearly stops.
Brain & AgingA Federally Backed Trial Got High-Dose Fish Oil Into the Brain Fluid. The Memory Scores Never Moved.
DHA in the spinal fluid climbed 17 percent. Cognitive scores rose 2.76 points on fish oil, 2.67 on placebo. Two years of high-dose pills bought a rounding error.
Brain & AgingThe Alzheimer's Field Spent Decades Trying to Destroy These Droplets. A Baylor Lab Says the Droplets Were Never the Problem.
A Baylor lab reports that tubulin redirects Tau and alpha-synuclein away from toxic clumping in the test tube. It is elegant mechanism work, and not yet a drug, an animal, or a person.
Brain & AgingThe Brain Was Starving Before the Plaques Showed Up: Alzheimer's Metabolic Reframe Has a Case, Not a Trial
A rising camp says failing mitochondria, not amyloid plaques, may drive Alzheimer's first. The biology is compelling and the amyloid monoculture earned its reckoning, but the metabolic side has its own retractions and not one human trial showing it works.
Brain & AgingThe amyloid-versus-tau war in Alzheimer's might be the wrong fight
A four-person UC Riverside chemistry group argues amyloid beta and tau compete for the same microtubule binding sites, a unifying mechanism that cuts under Alzheimer's research's three-decade amyloid-versus-tau fight.
Brain & AgingMagic Mushrooms and an 80-Year-Old's Memory: What the Hype Actually Has, and What It Doesn't
An 80-something woman with advanced Alzheimer's took five grams of mushrooms and started speaking again. The biology behind why that might happen is real. The trial base it rests on is thinner than the headlines admit.
Brain & AgingA molecule your body already makes coaxed exhausted brain cells back to fighting Alzheimer's
Spanish and Swiss researchers report that OLE, a fatty-acid amino-acid the body already makes, coaxed sluggish microglia to surround amyloid plaques and improve memory in Alzheimer's mice.
Brain & AgingA viral diabetes-and-dementia explainer left out the trial that just killed its big drug story
A widely shared "ten ways diabetes and dementia are linked" explainer is going around this week, and it skips the Phase 3 trial that, weeks earlier, demolished its brain-protection story for semaglutide.
Brain & AgingThe Shingles Vaccine Keeps Cutting Dementia Risk. The Reason May Not Be the Shingles.
Four big studies now tie the shingles vaccine to lower dementia risk. The most useful finding is that the same effect shows up with an RSV vaccine that shares its adjuvant.
Brain & AgingThe Same Mutations That Drive Blood Cancer Keep Turning Up in Alzheimer's Brains
A new Cell paper finds Alzheimer's brains are riddled with the same mutations that drive blood cancers, in the immune cells that are supposed to be protecting neurons.
Brain & AgingThe Alzheimer's Drug That Bets the Plaques Are a Symptom
An ETH Zurich team spent nearly twenty years tracing why Alzheimer's nerve cells run out of energy, and the answer points to a protein the amyloid-clearing drugs never touched.