alzheimers
13 stories tagged "alzheimers"
Anti-Tau Alzheimer's Drugs Keep Hitting Their Target and Missing the Disease
Tau is the new headliner at the Alzheimer's conference, but the anti-tau antibodies keep proving they bind the protein while doing nothing for patients. The clearest win so far is a blood test.
Brain & AgingA Brain Full of Plaques and a Mind That Held: The Cells That May Explain Alzheimer's Resilient Third
About a third of people whose brains show the full pathology of Alzheimer's never develop dementia. Dutch researchers say the difference may not be how many young neurons they have, but whether those cells switch on a survival program instead of dying.
Brain & AgingAlzheimer's Hitches a Ride on a Virus Your Neurons Tamed for Memory
In mice and in human Alzheimer's brains, toxic tau rides a protein called Arc, a virus your neurons domesticated for memory, from sick cells into healthy ones. Delete Arc and the spread nearly stops.
Brain & AgingA Federally Backed Trial Got High-Dose Fish Oil Into the Brain Fluid. The Memory Scores Never Moved.
DHA in the spinal fluid climbed 17 percent. Cognitive scores rose 2.76 points on fish oil, 2.67 on placebo. Two years of high-dose pills bought a rounding error.
Brain & AgingThe Alzheimer's Field Spent Decades Trying to Destroy These Droplets. A Baylor Lab Says the Droplets Were Never the Problem.
A Baylor lab reports that tubulin redirects Tau and alpha-synuclein away from toxic clumping in the test tube. It is elegant mechanism work, and not yet a drug, an animal, or a person.
Brain & AgingThe Brain Was Starving Before the Plaques Showed Up: Alzheimer's Metabolic Reframe Has a Case, Not a Trial
A rising camp says failing mitochondria, not amyloid plaques, may drive Alzheimer's first. The biology is compelling and the amyloid monoculture earned its reckoning, but the metabolic side has its own retractions and not one human trial showing it works.
Brain & AgingThe amyloid-versus-tau war in Alzheimer's might be the wrong fight
A four-person UC Riverside chemistry group argues amyloid beta and tau compete for the same microtubule binding sites, a unifying mechanism that cuts under Alzheimer's research's three-decade amyloid-versus-tau fight.
Brain & AgingA molecule your body already makes coaxed exhausted brain cells back to fighting Alzheimer's
Spanish and Swiss researchers report that OLE, a fatty-acid amino-acid the body already makes, coaxed sluggish microglia to surround amyloid plaques and improve memory in Alzheimer's mice.
Brain & AgingMagic Mushrooms and an 80-Year-Old's Memory: What the Hype Actually Has, and What It Doesn't
An 80-something woman with advanced Alzheimer's took five grams of mushrooms and started speaking again. The biology behind why that might happen is real. The trial base it rests on is thinner than the headlines admit.
Brain & AgingA viral diabetes-and-dementia explainer left out the trial that just killed its big drug story
A widely shared "ten ways diabetes and dementia are linked" explainer is going around this week, and it skips the Phase 3 trial that, weeks earlier, demolished its brain-protection story for semaglutide.
Brain & AgingThe Shingles Vaccine Keeps Cutting Dementia Risk. The Reason May Not Be the Shingles.
Four big studies now tie the shingles vaccine to lower dementia risk. The most useful finding is that the same effect shows up with an RSV vaccine that shares its adjuvant.
Brain & AgingThe Same Mutations That Drive Blood Cancer Keep Turning Up in Alzheimer's Brains
A new Cell paper finds Alzheimer's brains are riddled with the same mutations that drive blood cancers, in the immune cells that are supposed to be protecting neurons.
Brain & AgingThe Alzheimer's Drug That Bets the Plaques Are a Symptom
An ETH Zurich team spent nearly twenty years tracing why Alzheimer's nerve cells run out of energy, and the answer points to a protein the amyloid-clearing drugs never touched.