glp-1
32 stories tagged "glp-1"
A Daily Fiber Powder Eased Knee Arthritis Pain, and People's Grip Got Stronger Too
Six weeks of inulin, a prebiotic sold by the tub, cut knee pain 1.11 points more than placebo and added 4.62 kilograms of grip strength in a Nottingham trial, while the gut hormone GLP-1 rose alongside.
Metabolic & WeightThe 'Self-Destruct' Fat Shot Billed as Obesity Medicine Faces Its Pivotal Trial Below the Obesity Line
Caliway's CBL-514 shrank belly fat in small trials and drew obesity headlines at EASD, but its phase 3 caps enrollment below a BMI of 30 and grades flatter stomachs, not weight.
Drugs & FDAFederal Agents Seized Counterfeit Ozempic and Warned the Public. Prosecutors Say the Smuggling Kept Going for Months.
The counterfeits came from China with fake needles and packaging and sold to distributors at a discount. The indictment says the alleged scheme kept running for months after the FDA had already seized counterfeit Ozempic and warned the country.
Metabolic & WeightMounjaro Turned On Calorie-Burning Fat in Mice That Ate Exactly the Same Amount
Tirzepatide mice ate the same calories as the controls and still burned more, by firing up brown fat. Adults carry only a few grams of it, and it shrinks in exactly the people taking the drug.
Metabolic & WeightOne in Six Kids on Weight-Loss Drugs Was Diagnosed With a Nutrient Deficiency, and Only 5 Percent Got Nutrition Counseling
The alarm about kids going short on vitamin D on Ozempic-style drugs came from a study funded by Abbott, which sells the very nutrition drinks marketed to fill those gaps.
Metabolic & WeightCrash Diets Rewire Your Gut to Sabotage the Next One
In mice, transplanting the gut microbes of weight-cycled animals into healthy ones handed over the bingeing with them. Crash dieting reshapes the gut, and the diet industry keeps selling you the fix for damage its last plan made.
Nutrition & FoodThe Fat Hiding in Black and Green Rice Is a Cousin of the Body's Own Blood-Sugar Molecules
Hokkaido chemists screened 56 rice varieties and found the pigmented ones carry a lipid cousin of the body's own insulin-sensitizing fats. This study did not test it in people.
Metabolic & WeightOzempic Gave Old Mice a Diet's Longevity Payoff Without Slowing Their Metabolism
Semaglutide added 12 percent to old mice's median lifespan and matched calorie restriction on aging measures without slowing their metabolism the way dieting does. It was also female mice only, three months of dosing, and zero human longevity data under the fountain-of-youth headlines.
Metabolic & WeightThe Cheapest Measurement in the Exam Room Beat BMI and the Lancet's Four-Part Obesity Formula
BMI flagged 37 percent of the adults a body-fat scan called obese. On overall accuracy, a cloth tape around the waist caught far more and edged out the four-measurement framework built to fix BMI.
Metabolic & WeightYour Immune Cells Remember Obesity for Up to a Decade After the Weight Comes Off
CD4 T cells hold chemical marks of past obesity for an estimated five to ten years, which may help explain why the risk for diabetes and some cancers can linger long after the scale reads normal.
Metabolic & WeightBerkeley Dusted Off a Shelved 1970s Fat Compound That Burns Energy Instead of Appetite, and in Mice It Spared the Muscle
GLP-1 drugs quiet your appetite, and along with the fat they can pull out a real chunk of muscle. A shelved acetyl-CoA carboxylase inhibitor from the 1970s went after the other lever, energy burned, and in obese mice it left the lean mass alone.
Metabolic & WeightThe Exercise Paradox: Lousy for Losing Weight, Your Best Bet for Keeping It Off
A study of more than 1,100 people found activity did almost nothing for the pounds they shed, yet it was one of the strongest signals of whether that weight stayed gone.
Metabolic & WeightThe Hunger Neurons Ozempic Was Meant to Silence Are the Ones Burning Your Fat
Silence the hunger neurons and semaglutide keeps killing appetite, but in Yale's female mice the lost fat came back within 15 days.
Brain & AgingThe Craving Brake Nobody Mapped: How GLP-1 Drugs Quiet Cravings From the Lateral Septum
The anti-craving effect pushing people to use a diabetes shot off-label against drinking traces to a brain region built to inhibit, not to reward, and the human evidence is still just two small trials deep.
Metabolic & WeightThe Peptide Boom Hides One Divide: Human Trials on a Few, Rodent Data and Case Reports on the Rest
Semaglutide and tirzepatide erased up to 22 percent of body weight in trials with thousands of patients. The research-only peptides sold beside them, like BPC-157, have not completed a single published human efficacy trial. A popular 2026 guide lists them as equals.
Metabolic & WeightYour Fat Cells Remember Being Fat, and That Memory Outlasts the Weight Loss
Your body defends its heaviest weight for years after you lose it, which is why the rebound isn't weak willpower and why the injection only works while you keep paying for it.
Nutrition & FoodA Daily Scoop of Chicory Fiber Eased Knee Arthritis, and It Moved the Same Gut Hormone as Ozempic
Twenty grams of chicory fiber a day matched a physiotherapy app for knee arthritis pain, and only one person in the fiber group quit. The hormone it nudged is the one Ozempic is built to imitate.
Metabolic & WeightOrforglipron Reaches Deep Into the Brain's Reward Circuit and Turns the Dopamine Down
In mice engineered with human GLP-1 receptors, the new oral pills reached the central amygdala, a deep reward hub, and thinned the dopamine payoff of eating for pleasure. The government's addiction institute is already watching.
Metabolic & WeightThe GLP-1s That Barely Move the Scale Don't Cause Hair Loss, and That's the Clue Everyone Missed
Women on semaglutide shed hair at about twice the rate of men, and the weakest GLP-1s show almost no signal, which points the cause away from the follicle and straight at how fast the weight comes off.
Metabolic & WeightThe Mice Ate More and Got Leaner. The Switch Was One Amino Acid, Turned Down.
USC mice on a low-protein, methionine-tuned diet ate as many calories as the junk-food group and still lost fat, while their own bodies pumped out more GLP-1. The scientist behind it also owns the company selling longevity diets.
Metabolic & WeightBoth Groups Lost the Same Seven Kilos. Only the Calorie Counters Had to White-Knuckle It.
In an 18-month Adelaide trial, fasting and daily calorie-cutting stripped off the same seven kilos, but for the counters part of that loss ran on constant conscious restraint the fasters' scores never showed.
Metabolic & WeightSwitch Off One Protein Called Mitch, and Cells Start Eating Their Own Fat
Women with obesity carry more of it. Disable it in mice and they turn lean and muscular at once, the opposite of what the injectable weight-loss drugs do to your body.
Metabolic & WeightObesity Stopped Denting Older Adults' Metabolic Numbers: In the Young It's Biting Harder Than Ever
For middle-aged and older adults, extra weight no longer tracks with the cardiovascular damage it once did. For the young, the same fat is biting harder and earlier. The lab panels converged; the fat didn't.
Metabolic & WeightThe Obesity 'Revolution' Everyone's Promising Comes From People Who'd Cash In On It
A new commentary says the GLP-1 era is just the prelude to a bigger obesity "revolution." The authors have direct financial stakes in what comes next, and the celebrated new pill loses less weight than the shot.