metabolic
31 stories tagged "metabolic"
One Hormone Starves the Brain and Floods the Heart: The FDA's First MCT8 Drug Treats Only the Flood
Emcitate is being called the first treatment for MCT8 deficiency, but its FDA label covers the racing heart and the wasting body, not the brain disability that defines the disease.
Nutrition & Food87 Trials Found the Whole-Grain Sweet Spot: Sixteen Markers Nudged Healthier, None of Them by Much
Sixty to a hundred grams of whole grain a day nudged weight, cholesterol, blood pressure and inflammation the right way across 87 randomized trials. The median trial ran eight weeks, every effect was tiny, and not one counted an actual heart attack.
Metabolic & WeightForever Chemicals, Pregnancy, and the Vitamin That Might Decide Who Gets Hurt
Early-pregnancy PFAS tracked with gestational diabetes in a 420-woman China cohort, but almost entirely in mothers already low on vitamin D. A 5,229-pregnancy US analysis found no added risk at all. The gap between them may come down to one cheap blood test.
Nutrition & FoodThe Fat Hiding in Black and Green Rice Is a Cousin of the Body's Own Blood-Sugar Molecules
Hokkaido chemists screened 56 rice varieties and found the pigmented ones carry a lipid cousin of the body's own insulin-sensitizing fats. This study did not test it in people.
Nutrition & FoodThe Whole-Grain Sweet Spot Is 4 to 6 Servings, and It Nudged Five Heart-Risk Numbers at Once
60 to 100 grams a day moved body weight, blood pressure, cholesterol, blood sugar and an inflammation marker together, the same cluster clinicians usually treat one number, and one prescription, at a time.
Metabolic & WeightThey Sniffed Dark Chocolate on an Empty Stomach and Cranked Out 18 More Reps
Twenty-three fasted men sniffed 90 percent dark chocolate and did roughly 18 more leg-extension reps than on water, without feeling like they'd worked any harder.
Metabolic & WeightOzempic Gave Old Mice a Diet's Longevity Payoff Without Slowing Their Metabolism
Semaglutide added 12 percent to old mice's median lifespan and matched calorie restriction on aging measures without slowing their metabolism the way dieting does. It was also female mice only, three months of dosing, and zero human longevity data under the fountain-of-youth headlines.
Metabolic & WeightA Blueberry Compound Pulled Fat Out of Muscle Cells by Saving the Protein That Burns It
Pterostilbene didn't switch on fat-burning in muscle cells. It stopped them from destroying the protein that runs it, and the stored fat came apart. The catch: this happened in a dish, and you can't eat your way to the dose.
Nutrition & FoodYour Gut Bacteria Decide Whether Sorbitol Is Harmless or a Liver Problem
Sorbitol was sold for decades as the inert, guilt-free sugar swap. In zebrafish stripped of their gut bacteria, WashU researchers watched the intestine's own sorbitol reach the liver and feed the same fructose-metabolism pathway that packs on liver fat.
Metabolic & WeightWhat Fluoride Does Once It Gets Past the Teeth
As Washington fights over whether to keep fluoridating tap water, the sharpest evidence on childhood fluoride and cardiovascular risk comes from places where the dose dwarfs anything out of a U.S. tap. The whole argument is about how much.
Metabolic & WeightYour Immune Cells Remember Obesity for Up to a Decade After the Weight Comes Off
CD4 T cells hold chemical marks of past obesity for an estimated five to ten years, which may help explain why the risk for diabetes and some cancers can linger long after the scale reads normal.
Metabolic & WeightThe Exercise Paradox: Lousy for Losing Weight, Your Best Bet for Keeping It Off
A study of more than 1,100 people found activity did almost nothing for the pounds they shed, yet it was one of the strongest signals of whether that weight stayed gone.
Metabolic & WeightFluoride and Kids' Hearts: The Reassuring Study Tested Water Below What US Taps Are Told to Add
Researchers measured fluoride and heart risk in 161 Iranian children, and the main analysis found no significant link. But they drank water below the level US taps are told to add, and a different adjustment flipped the numbers.
Metabolic & WeightThis Weight-Loss Hormone Protected Mouse Livers Without a Pound Lost. Novo Nordisk Supplied It and Put Two Scientists on the Study.
The hormone works through the same brainstem switch that makes weight-loss drugs nauseating, and the company developing it supplied the compound, funded the mouse study, and put two of its scientists on the author list.
Metabolic & WeightThe Hunger Neurons Ozempic Was Meant to Silence Are the Ones Burning Your Fat
Silence the hunger neurons and semaglutide keeps killing appetite, but in Yale's female mice the lost fat came back within 15 days.
Metabolic & WeightHow 244 People Cut 357 Calories a Day Without Eating Less Food
The people on the low-fat vegan diet didn't count calories or shrink portions. They ate the same weight of food and took in hundreds fewer calories a day. The group that ran the trial also has a stake in what you conclude.
Brain & AgingAny Amount of Midlife Movement Tracked With Slower Brain Decline, Most Clearly in Mexican American Adults
In a San Antonio cohort followed since 1979, any physical activity in midlife tracked with slower brain decline, and the link showed up most clearly in the Mexican American adults Alzheimer's research keeps leaving out.
Metabolic & WeightA Brain Protein Made Female Mice Overeat Fat, and the $441,000 Obesity Drug Worked Weakest on Them
Dietary fat switches on an appetite-protecting brain protein in male mice but not females. Delete it and the females overeat fat, gain more weight, and setmelanotide, the $441,000-a-year MC4R obesity drug, loses much of its appetite-suppressing punch on them.
Nutrition & FoodThe Study Telling You Not to Bother Cutting Sweet Foods Was Co-Funded by the Soda and Sweetener Industry
The Sweet Tooth Trial found no reason to reduce sweet-tasting foods. Its private funders include the soda industry's trade group and the International Sweeteners Association.
Metabolic & WeightThe Fat Rebound Pediatricians Watch For at Age Six: Measure the Waist, and It Turns Out to Be Muscle and Bone
Waist-to-height ratio tracks body fat with about 90 percent accuracy. In 2,410 American kids it kept falling straight through the age when BMI says the fat comes roaring back.
Nutrition & FoodA Microwave Can Fry a Potato That Soaks Up Less Oil: That Isn't the Same as a Healthier Fry
University of Illinois engineers made French fries that hold less oil by frying them from the inside. Nobody ran a taste test, nobody measured the acrylamide, and the pitch was aimed at food manufacturers.
Nutrition & FoodThe NIH Weighed Every Meal to a Tenth of a Gram. Four AI Calorie Apps Undercounted by up to 345.
In a locked NIH metabolic kitchen where every ingredient was weighed to 0.1 grams, MyFitnessPal, Lose It!, CalAI, and Appediet each read a plate and undercounted it by a quarter to a third, missing the fat most of all.
Metabolic & WeightThe GLP-1s That Barely Move the Scale Don't Cause Hair Loss, and That's the Clue Everyone Missed
Women on semaglutide shed hair at about twice the rate of men, and the weakest GLP-1s show almost no signal, which points the cause away from the follicle and straight at how fast the weight comes off.
Metabolic & WeightThe Mice Ate More and Got Leaner. The Switch Was One Amino Acid, Turned Down.
USC mice on a low-protein, methionine-tuned diet ate as many calories as the junk-food group and still lost fat, while their own bodies pumped out more GLP-1. The scientist behind it also owns the company selling longevity diets.