aging
25 stories tagged "aging"
Mayo's Tomato Compound Against 'Zombie Cells' Was Tested in Old Mice, Not People
Tomatidine quieted aging cells in elderly mice and in human cells grown in a dish. Two of its coauthors run the company licensing tomatidine patents, and trials of other senolytic drugs in people have missed their primary endpoints.
Brain & AgingPull One Protein Out of a Human Cancer Cell and Its Jumping Genes Wake Up Within Two Hours
Removing either of two CCR4-NOT proteins from a human colorectal cancer cell line raised transcription at about 77 percent of tracked LINE jumping genes within two hours, yet the two removals pushed jumping-gene RNA lifespans in opposite directions.
Metabolic & WeightThe Molecule Behind Fecal Odor Had the Strongest Death Link in a New Blood Aging Panel
In 18,476 people, a blood clock linked smoking and fried food to an older metabolic age and exercise and mixed grains to a younger one. The molecule most tied to death is made by gut bacteria.
Autoimmune & InflammationThe Rogue Clones in Aging Blood Shrug Off the Inflammation That Wears Down Their Neighbors
By 70, more than half of people carry mutant blood-stem-cell clones on sensitive tests. Marrow maps show them living amid inflamed, fibroblast-rich pockets, and the mutants barely flinch at the inflammation.
CancerThe Marrow Around a Common Aging Blood Clone Is Already Inflamed and Starting to Scar
Clonal hematopoiesis turns up in 10 to 20 percent of adults over 60, and the blame has always landed on the mutant cell. Single-cell maps of living marrow show the tissue around it inflamed and laying down scar before any cancer appears, which suggests the clone is not acting alone.
Metabolic & WeightHard Intervals Held the Lean Mass That Gentle Cardio Lost. The Researchers Say Don't Oversell It.
Treadmill intervals held onto lean mass in healthy older adults while steady moderate cardio chipped away at it. The researchers' own verdict on the difference: small, and not clinically meaningful once you account for the wobble in a body scan.
InvestigationsYour Country's Estimated Heat Death Toll Depends on Which Heat Metric the Modelers Picked
Japan recorded 1,522 heatstroke deaths in 2020. One model called that unusually high; a better-fitting one put it inside the expected range. Europe's estimated heat tolls bend to the same kind of choice.
Nutrition & FoodThe Older Adults Whose 'Biological Age' Dropped Ate More Carbs and Kept the Meat
The omnivorous, low-fat, high-carbohydrate group showed the strongest drop. The keto-style omnivore group was the only one of four that didn't budge at all.
Brain & AgingThe 'Supplement Reverses Aging' Headline Skips the Brain Surgery on the Mouse
The mouse study now going around as an anti-aging supplement win leaves out the part where the real reversal took a virus carrying a gene, injected into the hypothalamus.
Brain & AgingThe Cell Mistakes Its Own Broken DNA for a Virus, and the Panic Helps Wreck a Fast-Aging Fish
For decades the broken DNA got the blame. In fast-aging fish carrying a DNA-repair disorder, a major driver turned out to be the cell's own inflammatory overreaction, and silencing the sensor eased the ruin.
Brain & AgingScientists Quieted Aging Inflammation in Mice by Starving Zombie Cells, Not Killing Them
For years the anti-aging plan was to hunt down and kill the senescent cells driving inflammation. A Mayo and Sanford Burnham team quieted that inflammation in mice instead, by blocking the carrier that feeds their mitochondria the acetyl-CoA used to pry open inflammatory genes.
Metabolic & WeightOzempic Gave Old Mice a Diet's Longevity Payoff Without Slowing Their Metabolism
Semaglutide added 12 percent to old mice's median lifespan and matched calorie restriction on aging measures without slowing their metabolism the way dieting does. It was also female mice only, three months of dosing, and zero human longevity data under the fountain-of-youth headlines.
Drugs & FDAThe 'Bone-Building Switch' Is Back in the Headlines. It Was Tested in Mice, and Only Mice
A publicly funded Leipzig compound rebuilt bone in ovariectomized mice, 8 per treated group. More than a year later the same experiment is still being sold to readers as a way to keep their bones strong for life.
Brain & AgingA Kinesiologist Argues Aging Has a Third Clock, and It Fades First
Georgia Southern's Li Li argues aging has a third clock, movement span, that starts narrowing before any disease shows up. A compelling reframe with one catch: it's an opinion paper carrying zero new data.
Brain & AgingA Stanford Lab Deleted One Immune Receptor and Its Old Mice Barely Aged
Stanford says it found one big reason we age. The proof is a genetically engineered mouse, no such drug exists for people, and the senior author already holds patents on inhibiting the receptor she wants blocked.
Metabolic & WeightThe 123 Percent Death-Risk Number in the Vitamin D Headlines Was Never Tested as a Pill
An observational study of 5,520 older Britons tied belly fat plus low vitamin D to a 123 percent higher death risk. Hand people the actual pill in a randomized trial and mortality drops about 5 percent, with nothing at all for the heart.
Brain & AgingBracing for a Fall That Hasn't Happened Yet: The Bargain the Aging Ankle Strikes
Falls kill more older Americans than any other injury, and a study of 107 walkers points at the body's own defense: the aging ankle appears to brace for stability, buying it with a shorter, slower, more tiring stride.
Nutrition & FoodThey Doubled the Recommended Protein This Year. 350 Studies Say That's Backwards for Sedentary Adults.
Federal guidance now tells you to eat nearly twice the protein it used to. A University of Wisconsin review of more than 350 studies argues that for people who don't train hard, the extra may be speeding up the aging they're trying to outrun.
Nutrition & FoodIn the Lab, Coffee Flipped an Anti-Aging Switch. The Caffeine Barely Did.
Stephen Safe's lab reported that coffee's polyphenols, more than its caffeine, switch on a cellular stress-defense receptor. Every experiment ran in a dish, and the anti-aging headline traveled a great deal further than the data.
Brain & AgingSenescence Built Your Hands Before It Ever Aged Your Skin
Cellular senescence, the process blamed for aging and disease, is also how an embryo sculpts fingers and clears its own tissue. That double life scrambles the anti-aging industry's tidy 'kill the zombie cells' pitch.
Metabolic & WeightThe Belly Fat You Gain After 40 Comes From a Cell That Barely Existed in Your Twenties
Transplant old fat stem cells into a young mouse and they keep churning out fat; young ones in an old mouse stay quiet. In mice, the fat-making program travels with the cell, not the body around it.
Brain & AgingThey Told Older Adults the Pill Was Fake. Their Memory Got Better Anyway.
A 90-person Italian trial gave older adults inert pills and told one group flat-out they were fake. That group improved as much as the deceived one. Here is what that does and doesn't prove.
Nutrition & FoodThey Call It Aging. Sometimes It's a Vitamin Your Doctor Forgot to Check.
New Cornell research explains how B12 deficiency starves muscle of energy, and why the standard test your doctor orders can call the problem aging.
Nutrition & FoodThe Protein Numbers on the Government Charts Were Never Meant to Help You Thrive
A new Frontiers in Nutrition perspective argues official protein and exercise guidelines were built to prevent deficiency, not to maximize healthspan, and that older adults in particular need far more.