inflammation
28 stories tagged "inflammation"
Pull One Protein Out of a Human Cancer Cell and Its Jumping Genes Wake Up Within Two Hours
Removing either of two CCR4-NOT proteins from a human colorectal cancer cell line raised transcription at about 77 percent of tracked LINE jumping genes within two hours, yet the two removals pushed jumping-gene RNA lifespans in opposite directions.
Brain & AgingPsilocybin Trial's Banked Blood Shows Parkinson's Inflammation Markers Still Lower a Month Later
Five inflammatory signals were still below baseline a month after the second psilocybin session, in blood banked from nine Parkinson's patients in an uncontrolled UCSF pilot whose investigators carry psychedelic-industry ties.
Brain & AgingClear Most of the Brain's Microglia and Alzheimer's Mice Sleep Two Hours More, Plaque Load Unchanged
In amyloid mice, plaque piled up while lost sleep held flat, and the sleep came back when most microglia were cleared. That is an awkward result for an industry selling plaque removal.
Autoimmune & InflammationThe Rogue Clones in Aging Blood Shrug Off the Inflammation That Wears Down Their Neighbors
By 70, more than half of people carry mutant blood-stem-cell clones on sensitive tests. Marrow maps show them living amid inflamed, fibroblast-rich pockets, and the mutants barely flinch at the inflammation.
CancerThe Marrow Around a Common Aging Blood Clone Is Already Inflamed and Starting to Scar
Clonal hematopoiesis turns up in 10 to 20 percent of adults over 60, and the blame has always landed on the mutant cell. Single-cell maps of living marrow show the tissue around it inflamed and laying down scar before any cancer appears, which suggests the clone is not acting alone.
Metabolic & WeightThe Cells That Should Heal a Diabetic Wound Are Keeping It Open
The immune cells meant to close a diabetic ulcer get stuck attacking it instead, a Shanghai review argues. It maps the biology in detail, then concedes its central framework is contested and the fixes it points to have never been tested in a person.
Nutrition & FoodMen Who Iced After Lifting Gained a Third of the Thigh Muscle Their Peers Did
Twelve weeks of cold water after leg day left men with 103 grams of new quadriceps muscle against 309 for those who cycled, and most of the recovery aisle is sold on soreness, not gains.
Autoimmune & InflammationNovo Nordisk Paid to Count the Inflamed Heart Failure Patients Its Antibody Is Chasing
Three big studies putting heart failure inflammation anywhere from 38% to more than half were funded by Novo Nordisk, whose IL-6 antibody missed its first outcomes trial in July. Their predictor tables point at fat, smoking and kidneys.
Autoimmune & InflammationKnee Pain Fell From 7 to 3 After This Artery Procedure, but It Keeps Struggling to Beat a Fake One
Berlin doctors plugged inflamed knee vessels with gelatin beads built to dissolve within hours, and median pain fell from 7 to 3 over a year. Nobody got a sham, and the Rotterdam trial that used one calls the effect mainly placebo.
Autoimmune & InflammationPesticides Outlawed in the 1970s Are Still in Women's Blood, and They Track With Chronic Inflammation
French scientists screened 45 banned or barely-regulated chemicals in 468 women's blood. Two pesticides cancelled decades ago still tracked with elevated inflammation, and the PFAS quietly pushed an immune signal down.
Nutrition & Food87 Trials Found the Whole-Grain Sweet Spot: Sixteen Markers Nudged Healthier, None of Them by Much
Sixty to a hundred grams of whole grain a day nudged weight, cholesterol, blood pressure and inflammation the right way across 87 randomized trials. The median trial ran eight weeks, every effect was tiny, and not one counted an actual heart attack.
Metabolic & WeightThe Headlines Blamed Stress. The Data Blamed Belly Fat, Cigarettes, and Poverty.
In 488,079 UK adults, chronic inflammation tracked with a heart quietly remodeling into a smaller, stiffer pump. The loudest drivers were belly fat, cigarettes, and poverty. The paper points at a druggable inflammation pathway; its senior author discloses fees and grants from Bayer and Google's Cali
Autoimmune & InflammationThe Air Never Arrives One Pollutant at a Time, but the Rules Pretend It Does
In a big European analysis, almost every pollutant tested on its own came back borderline. Measure the whole mixture the way it actually reaches the lung, and the adult-asthma signal shows up.
Brain & AgingThe Cell Mistakes Its Own Broken DNA for a Virus, and the Panic Helps Wreck a Fast-Aging Fish
For decades the broken DNA got the blame. In fast-aging fish carrying a DNA-repair disorder, a major driver turned out to be the cell's own inflammatory overreaction, and silencing the sensor eased the ruin.
Brain & AgingScientists Quieted Aging Inflammation in Mice by Starving Zombie Cells, Not Killing Them
For years the anti-aging plan was to hunt down and kill the senescent cells driving inflammation. A Mayo and Sanford Burnham team quieted that inflammation in mice instead, by blocking the carrier that feeds their mitochondria the acetyl-CoA used to pry open inflammatory genes.
Autoimmune & InflammationA Fat 'Brake' Eased Pain in 49 Men but Barely Touched the Swelling
UCL researchers gave 49 healthy men a drug GlaxoSmithKline shelved after early trials. Pain resolved faster and a class of immune cells shrank, but the heat, redness, and swelling showed no significant change.
Brain & AgingDirty Air Is Linked to 16 Percent More Inflammation in Your Blood. Does That Damage Reach Your Brain?
Each step up in long-term fine-particle exposure is tied to nearly 16 percent higher inflammation in older adults' blood, and a CHARLS analysis asks whether that same signal is what wears down the aging brain.
Brain & AgingA Stanford Lab Deleted One Immune Receptor and Its Old Mice Barely Aged
Stanford says it found one big reason we age. The proof is a genetically engineered mouse, no such drug exists for people, and the senior author already holds patents on inhibiting the receptor she wants blocked.
Autoimmune & InflammationHow Fiber Teaches a Self-Erasing Gut Wall to Remember for Two Weeks
Butyrate, the compound gut bacteria make from fiber, reprogrammed the intestinal lining of mice to keep raising IL-10 and blunting colitis for 2 weeks after the last dose, and the imprint held even in mice with no gut bacteria at all.
Autoimmune & InflammationOne Protein Keeps Your Immune System's Peacekeeper Cells From Switching Sides
Regulatory T cells are supposed to be the immune system's off switch. Strip out a protein called TIF1γ and, under inflammation, they lose that identity, start producing an inflammatory cytokine, and join the attack.
Autoimmune & InflammationThe Body's Own Brake on Inflammation: Mapped in 2015, Still Not in a Pill
A kinase called MST4 rides the brake on TRAF6, the protein that lets inflammation spiral, doing gently from inside the cell what broad autoimmune drugs force from the outside. Researchers mapped it in 2015. No pill uses it yet.
Autoimmune & InflammationThe Lungs May Be Where Rheumatoid Arthritis Actually Starts
Across Italy, South Korea, and California, higher fine-particle pollution tracks more RA flares and more new cases, and the biology keeps pointing at the airway, not the knee.
Autoimmune & InflammationA 30-Minute Sauna Floods the Blood With Immune Cells, and the Heat Isn't What Triggers Them
Finnish researchers put 51 people in a 73-degree sauna and watched every class of white blood cell surge, then found the surge had almost nothing to do with how hot anyone actually got.
Autoimmune & InflammationA Petri Dish of Angry Immune Cells, a Little Ultrasound, and a Very Big Headline
UAH researchers used sound waves to shift immune cells from attack mode toward repair. The press release said 'stop arthritis before it starts.' The experiment never touched a joint.