supplements
34 stories tagged "supplements"
A Daily Fiber Powder Eased Knee Arthritis Pain, and People's Grip Got Stronger Too
Six weeks of inulin, a prebiotic sold by the tub, cut knee pain 1.11 points more than placebo and added 4.62 kilograms of grip strength in a Nottingham trial, while the gut hormone GLP-1 rose alongside.
Brain & AgingMayo's Tomato Compound Against 'Zombie Cells' Was Tested in Old Mice, Not People
Tomatidine quieted aging cells in elderly mice and in human cells grown in a dish. Two of its coauthors run the company licensing tomatidine patents, and trials of other senolytic drugs in people have missed their primary endpoints.
Drugs & FDAMice Trained to Spot THC Gave the THC Answer for CBN, the Sleep-Gummy Cannabinoid
Mice given CBN twice daily for five days grew tolerant and twitched once a receptor blocker cut it off. A Canopy Growth sleep trial of CBN found about 0.5 fewer awakenings a night and missed its main measure.
Brain & AgingThe Omega-3 Trial Headlined as a Brain-Health Bust Was Built to Measure Spinal Fluid
Two years of high-dose DHA reached the spinal fluid of older adults exactly as planned. The memory scores behind the "no benefit" headlines were an exploratory outcome, and 38 percent of volunteers dropped out.
CancerThe Vitamin C Trial That Missed Its Goal and Counted 11 Deaths Against 24
Copenhagen and USC researchers gave 1,000 mg of plain vitamin C a day to people with pre-leukemic blood disorders. The mutant clones grew regardless, but over three years of follow-up 11 patients assigned to the vitamin died, against 24 assigned to placebo.
Brain & AgingThe Amino Acid That Sharpened Old Mice's Memory Made Neuron Loss Worse in Alzheimer's Mice
D-serine improved memory in old mice in a 2023 study now recirculating as news. Given to Alzheimer's model mice, the same amino acid made neuron loss worse, and the human trial behind the hype was a single dose.
Nutrition & FoodVitamin D2 Supplements Lower the Vitamin D3 Already in Your Blood
Pooling randomized trials, Surrey researchers found people taking vitamin D2 ended up with less circulating vitamin D3, the form sunlight makes, than people who took none, by as much as 18 nmol/L.
Brain & AgingIn Aging Brains, Thicker Myelin Showed Up Where Thinking Fell Fastest
In brain tissue from a subset of 866 Scots tested from age 70 to 82, the fastest decliners had smaller nerve fibers, thicker myelin and fewer myelin-making cells carrying the stress protein NRF2.
Nutrition & FoodMen Who Iced After Lifting Gained a Third of the Thigh Muscle Their Peers Did
Twelve weeks of cold water after leg day left men with 103 grams of new quadriceps muscle against 309 for those who cycled, and most of the recovery aisle is sold on soreness, not gains.
Brain & AgingD-Serine Helped Old Mice in the Maze and Did Nothing for Their Skin or Bones
Restoring the protein menin in one patch of hypothalamus gave 20-month-old mice thicker skin, more bone and better learning. D-serine, the amino acid now in the headline, improved only the learning, and the one trial in healthy older adults that both news stories cite gave each person a single dose
Metabolic & WeightMulberry Blunts Your Blood Sugar by Handing the Carbs to Your Gut Bacteria
Mulberry's post-meal glucose effect has been tested in people across 12 trials. The gut-microbiome makeover sold on the strength of it still exists only in mice and petri dishes.
Metabolic & WeightA Creatine-Industry Advisor Ran the Study Behind the 'Skip the Gym' Headlines
A new trial says creatine builds lean mass without exercise, and his own society's journal published it. The measurement it leaned on is the one creatine is known to inflate with water.
Nutrition & FoodTwo Labs on Two Continents Watched a Pomegranate Compound Relax Stiff Mouse Hearts
Heart failure with preserved ejection fraction has few disease-modifying options. A gut metabolite from pomegranates and walnuts, already sold as a supplement, improved measures of heart function up to 80 percent in mice.
Brain & AgingAlzheimer's Drugmakers Bet on Raising This Brain Sugar. Glucosamine May Be Overfeeding It.
In UF Health records, people with mild cognitive impairment who took the joint supplement were 25 percent more likely to slip into dementia. Glucosamine feeds the same brain chemistry a failed Alzheimer's drug was built to raise.
Nutrition & FoodCalcium and Vitamin D Cut Hip Fractures 16 Percent. The Authors Called That 'Little to No Meaningful Benefit.'
The combined calcium and vitamin D arm cut hip fractures with a confidence interval that cleared significance. Then a bar the researchers set for themselves, one that would take more than halving hip fractures to meet, turned the result into a headline telling people to stop.
Brain & AgingThe 'Supplement Reverses Aging' Headline Skips the Brain Surgery on the Mouse
The mouse study now going around as an anti-aging supplement win leaves out the part where the real reversal took a virus carrying a gene, injected into the hypothalamus.
CancerThe Women Low on Vitamin D Were Three Times as Likely to Wake From a Mastectomy in Serious Pain
Ninety-two breast cancer patients went into a mastectomy deficient in vitamin D; they were three times as likely to be in serious pain afterward and drew far more from the tramadol pump than the women whose levels were fine.
Brain & AgingThe Sea Squirt That Reverses Aging Is a Mouse Study From 2022. The Capsules Are Already on Amazon.
The mice got 300 milligrams per kilogram by feeding tube, five days a week, for two months. The human trials used about a milligram a day, most were funded by the companies selling the capsules, and the largest could not beat placebo.
Metabolic & WeightA Blueberry Compound Pulled Fat Out of Muscle Cells by Saving the Protein That Burns It
Pterostilbene didn't switch on fat-burning in muscle cells. It stopped them from destroying the protein that runs it, and the stored fat came apart. The catch: this happened in a dish, and you can't eat your way to the dose.
Brain & AgingThe Amino Acid Sold for Focus Tracked Fewer Years for Men, Not Women
In more than 270,000 people, men with higher blood tyrosine died sooner, by nearly a year on the genetic estimate. Women showed no clear lifespan signal. The amino acid is sold in capsules for focus.
Nutrition & FoodBeef-Level B12 in Spirulina: The Study Measured the Tank, Not a Human
An Icelandic supplement maker's light-tuned spirulina tested at beef-level active B12. The reading was taken from the biomass in a reactor. No one has yet fed it to a person to see whether the body can absorb it.
Nutrition & FoodWhat Probiotics Actually Do for Autistic Kids Isn't What the Label Promises
A review pooling about 1,000 participants found the clearest probiotic effect in autistic children lands on the gut, not behavior. The supplement aisle sells the reverse.
Brain & AgingThe Vitamin D Trials That Found No Brain Benefit Never Tested This Dose
Fifty-four older adults with failing sleep and early memory loss, and the ones taking 5,000 IU of vitamin D a day scored 13 percent higher on a standard cognitive test. The major null trials never tested that dose.
Metabolic & WeightThe 123 Percent Death-Risk Number in the Vitamin D Headlines Was Never Tested as a Pill
An observational study of 5,520 older Britons tied belly fat plus low vitamin D to a 123 percent higher death risk. Hand people the actual pill in a randomized trial and mortality drops about 5 percent, with nothing at all for the heart.