Cancer
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The Women Low on Vitamin D Were Three Times as Likely to Wake From a Mastectomy in Serious Pain
Ninety-two breast cancer patients went into a mastectomy deficient in vitamin D; they were three times as likely to be in serious pain afterward and drew far more from the tramadol pump than the women whose levels were fine.
CancerThe Study Breaking Pancreatic Cancer's 'Shield' Was Co-Written by the Drug's Maker
The 'breakthrough' bought engineered mice eleven extra days, its headline human numbers come from a post-hoc subgroup, and one author is the chief scientist of the company that makes the drug.
CancerMD Anderson Made the Case for Radiation Cleanup After Immunotherapy. Then Its Own Trial Undercut It.
In the oligometastatic subgroup the strategy was built for, small and underpowered, the patients who added radiation trended the wrong way: median survival of 42 months against 75.8 for the drugs alone.
CancerUCLA Can Grow Thousands of Cancer-Fighting Cell Doses in Six Weeks. Every Patient So Far Has Been a Mouse.
The lab put a $5,000-a-dose price on an off-the-shelf cancer therapy grown from cord blood that controlled tumors in mice with ovarian cancer and melanoma. No human has received it.
CancerThe Gene That Derails Brain Development Is Also a Brake on Your Killer T Cells
The same gene whose failure derails brain development in children sits like a brake on the CD8 T cells your body uses against chronic hepatitis B and cancer. Take the brake off in the lab, and their fate reroutes toward fighters that do not burn out.
CancerSummit's $500 Million Lung Drug Split the Curve Patients Can't Feel
Ivonescimab delayed tumor progression by 2.4 months in EGFR-mutated lung cancer, but its overall-survival curve never cleared statistical significance and serious treatment-related adverse events nearly doubled.
CancerFused Into One Cell, a Neutrophil and a Macrophage Ate Tumors Two Ways
CAR-macrophage therapy keeps stalling in solid tumors: it can't get in, and it can't finish. Fuse a neutrophil onto it and, in mice, one dose shrank the tumor and kept it from coming back.
CancerThe Breast Cancer Cells That Hide From Chemotherapy Were Already There Before the First Dose
British researchers mapped where dormant breast-tumor cells hide, inside protective pockets of immune and connective cells, and found cells resembling therapy-resistant survivors already parked there before treatment begins.
CancerTwenty People, No Control Arm, and a Startup on the Side: Reading the Pancreatic Cancer Vaccine's Fine Print
Ninety percent of twenty volunteers made KRAS-specific T cells. None was shown to avoid cancer. Two of the investigators co-founded the company that licensed the shot from Johns Hopkins, which stands to collect royalties.
CancerDecades of Cancer Warning Signs, and Still No Proof They Save Lives
England's cancer-awareness campaigns sent more people to the doctor for a decade. The reviews still can't show they caught a single cancer earlier or cut deaths, while the cancers that kill fastest stay silent until it's already too late.
CancerHigh Blood Sugar Hands Cancer Cells a Cloak the Immune System Can't See Through
Grown in a fluid built to mimic the human body, cancer cells used excess glucose to thicken a sugar coating that hid them from immune cells, an effect that never showed up in the standard lab dishes used across cancer biology.
CancerThe Executioner's Second Job: A Death Enzyme That Also Calls NK Cells to the Tumor
Caspase-3, the enzyme biology calls the executioner, turns out to carve a hidden, nucleus-bound form of interleukin-18 that summons NK cells to hunt tumors, a role the study says had gone unrecognized.
CancerA New Cancer 'Weapon' That Has Only Ever Slowed Tumors in Mice
Stanford's tissue-resident natural killer cells slowed melanoma and head-and-neck tumors in mice. John Sunwoo warned against reading too much into that. The coverage read plenty into it anyway.
CancerUC Irvine's 'Framework' for Safer CAR-T Is a Hypothesis Essay, Not a Study
The senior author consults for Kite Pharma, whose Yescarta accounted for all 6 grade-5 neurotoxicity deaths in the cited review's real-world data, the exact harm the paper proposes to treat.
CancerThe Cells That Heal Wounds Are Feeding Breast Cancer Its Nerves
University of Oklahoma researchers blocked the protein in mice and triple-negative tumors grew far less. In patients, all they have is a correlation and a drug, already sold for something else, that has never been tried against breast cancer.
CancerThe Cancer Trials That Buried Vitamin C Never Put It in a Vein
Mayo's famous trials gave advanced cancer patients vitamin C by mouth and found nothing. A randomized trial that delivered it by IV, at a dose pills cannot reach, doubled survival in metastatic pancreatic cancer.
CancerChemo-Surviving Ovarian Cancer Cells Release Fructose to Loosen the Tumor Next Door
The same cholesterol-starving mechanism that loosens tumor cells implicates statins, the pills 39 million Americans take, yet the researchers who found it say keep taking them anyway.
CancerThe Reason Immunotherapy Bounces Off Prostate Cancer: Tumors Chew Off a Genetic Tail to Blind the Immune System
Prostate tumors overproduce a protein that destroys the immune system's docking targets. A CRISPR tool that blocks the trick made checkpoint drugs work again, so far only in mice.
CancerThe Genes Driving Cancer's Growth Are the Same Ones It Keeps Breaking
The same super-enhancers that make a tumor grow keep snapping its DNA, and the botched repairs are where the next mutations come from. The finding is real, careful, and already a year old.
CancerIn 2021, Creatine Spread Cancer in Mice. This Week, a UCLA Lab Said It Fights It.
A UCLA study found creatine energized cancer-fighting immune cells in mice and lab dishes. It was never tested in a patient, and a separate line of research says the same supplement feeds metastasis.
CancerGlioblastoma Craves Sugar. Oregon State Coated a Gene Therapy in It and Rode Straight Past the Blood-Brain Barrier.
Glioblastoma overexpresses the same sugar transporter that guards the brain. Oregon State researchers used that greed to smuggle a tumor-suppressor gene into tumors, and mouse survival rose 50 percent.
CancerA Week Instead of a Month: The Faster Prostate Radiation Was Only "As Safe" on the Coarser Ruler
PACE-C put five-fraction radiation against the four-week course in 1,208 men. On the old grading scale they matched. On the finer one the short course logged 17 percent bowel toxicity against 10 percent, and the trial still can't say whether the shorter beam controls cancer as well.
CancerThe Same Cancer Mutation, Opposite Effects: What 581 Mouse Tumors Say About Who Gets Sick
Cambridge and Yale gave four strains of mice one identical dose of a carcinogen. The tumors converged on the same pathway but took four different genetic routes to get there, and today's screening ignores the reason.
CancerThe Evolutionary Fix for Drug Resistance Works Best on a Tumor Too Small to Find
City St George's mathematicians say hitting a tumor at its weakest moment can drive it extinct. Their own model clears 95 percent only below 7 million cells, far smaller than any tumor a scan can find.