preclinical
10 stories tagged "preclinical"
A Petri Dish of Angry Immune Cells, a Little Ultrasound, and a Very Big Headline
UAH researchers used sound waves to shift immune cells from attack mode toward repair. The press release said 'stop arthritis before it starts.' The experiment never touched a joint.
Metabolic & WeightA Gut Microbe Was Feeding Ammonia to Sick Livers. A Michigan Peptide Cut Off the Supply in Monkeys.
The compound reversed severe fatty liver in monkeys by starving one ammonia-making gut bacterium. It also comes from a company its lead inventor founded, and no human has taken it for this.
Infectious DiseaseThe Nose-Spray TB Vaccine in Your Feed This Week Has Only Ever Worked in Mice
Johns Hopkins fused two genes into a nasal spray, added it to a drug cocktail, and cleared tuberculosis faster in mice. DNA vaccines have dazzled mice for thirty years and disappointed humans nearly every time. This one has not been in a person yet.
CancerFor Twenty Years, a Vitamin B12 Cancer Drug Has Worked in Mice, Dogs, and Rats. It Still Hasn't Reached a Human Trial.
Nitrosylcobalamin crossed the blood-brain barrier and pooled in a rat's brain tumor. This study didn't shrink one, the synergy ran in a petri dish, and the scientist behind the headlines holds the patents.
CancerThe "Secret Reason" Cancer Drugs Stop Working Was Published in February
A Montreal team's antibody against the SLAMF6 brake on T cells made the rounds this week as a fresh discovery. The paper went up in February, the work is in mice, and the antibody has not been given to a person.
Drugs & FDAA heart-attack drug just regrew kidney tissue in mice, and the receipts have no pharma on them
A UCLA monoclonal antibody designed to help hearts heal after a heart attack also repaired injured kidneys in mice, and it was developed without a dollar of pharma money.
Metabolic & WeightSleep apnea's heart damage may run through the gut, not the airway
Researchers at UCSD report that knocking out a single bile-acid receptor abolishes the arterial plaque sleep-apnea conditions would otherwise drive in mice. The mechanism fits the CPAP era's underwhelming trial record better than the airway story ever did.
CancerA Korean lab found cancer's DNA-repair off-switch. In a mouse.
A Korean state lab reports that a tool compound called UNI418 strips out the DNA-repair proteins cancer cells use to escape PARP inhibitors. The data are preclinical: cell lines and mouse xenografts. UNI418 is not yet a drug.
Autoimmune & InflammationFish oil rewired the T-cells in non-obese diabetic rats, and the glucose moved with them
A Brazilian team gave EPA-heavy fish oil to a non-obese diabetic rat strain for eight weeks. Glucose, insulin sensitivity, and lipids all moved in the friendlier direction. The T-cell balance shifted alongside them, and that is the part of the paper worth chewing on.
Nutrition & FoodYale's Olive Oil Cancer Story Did Not Actually Test Olive Oil
A Yale mouse study reported in Cancer Discovery is being sold as proof that olive oil fuels pancreatic cancer. The lab fed the mice purified oleic acid, the effect only showed up in males, and no one has tested it in a person.