longevity
36 stories tagged "longevity"
The Mediterranean Diet's Mitochondrial 'Boost' Comes From One Blood Draw in 49 Heart Patients
Older heart-rhythm patients who ate closest to the Mediterranean pattern carried more humanin and SHMOOSE, but nobody's diet was changed and both gaps landed at p = 0.046.
Nutrition & FoodNon-Dairy Creamer Overtook Sugar as the Biggest Source of Added Calories in American Coffee
Average coffee intake barely moved between 2003 and 2018, yet its calories climbed from 43 to 60 a day, and non-dairy creamer, not sugar, drove most of the rise.
Metabolic & WeightThe Molecule Behind Fecal Odor Had the Strongest Death Link in a New Blood Aging Panel
In 18,476 people, a blood clock linked smoking and fried food to an older metabolic age and exercise and mixed grains to a younger one. The molecule most tied to death is made by gut bacteria.
Metabolic & WeightThe Body's Deepest Fasting Changes Don't Begin Until Day Three
Twelve volunteers fasted on water for a week while scientists tracked 3,000 blood proteins. About one in three shifted, but the broadest whole-body changes held off until after day three, long past where most intermittent fasters ever go.
Brain & AgingA Gut Molecule Tied to Diabetes and Clogged Arteries Now Tracks With Alzheimer's Decline
In 1,196 cognitively healthy adults, the people with the most of one gut-made molecule in their blood declined fastest, and a genetic variant carried by about 43 percent was linked to higher levels.
Metabolic & WeightA Creatine-Industry Advisor Ran the Study Behind the 'Skip the Gym' Headlines
A new trial says creatine builds lean mass without exercise, and his own society's journal published it. The measurement it leaned on is the one creatine is known to inflate with water.
Nutrition & FoodThe Older Adults Whose 'Biological Age' Dropped Ate More Carbs and Kept the Meat
The omnivorous, low-fat, high-carbohydrate group showed the strongest drop. The keto-style omnivore group was the only one of four that didn't budge at all.
Brain & AgingThe 'Supplement Reverses Aging' Headline Skips the Brain Surgery on the Mouse
The mouse study now going around as an anti-aging supplement win leaves out the part where the real reversal took a virus carrying a gene, injected into the hypothalamus.
Brain & AgingThe Cell Mistakes Its Own Broken DNA for a Virus, and the Panic Helps Wreck a Fast-Aging Fish
For decades the broken DNA got the blame. In fast-aging fish carrying a DNA-repair disorder, a major driver turned out to be the cell's own inflammatory overreaction, and silencing the sensor eased the ruin.
Brain & AgingUSC Scanned 459 Aging Brains Across India. The Wiring Just Under the Cortex, Not the Gray Matter, Tracked Who Stayed Sharp.
In 459 older adults across India, healthier short-range wiring just beneath the cortex was tied to a weaker link between gray matter loss and cognition, and the tie was strongest in people with the least schooling.
Brain & AgingScientists Quieted Aging Inflammation in Mice by Starving Zombie Cells, Not Killing Them
For years the anti-aging plan was to hunt down and kill the senescent cells driving inflammation. A Mayo and Sanford Burnham team quieted that inflammation in mice instead, by blocking the carrier that feeds their mitochondria the acetyl-CoA used to pry open inflammatory genes.
Metabolic & WeightOzempic Gave Old Mice a Diet's Longevity Payoff Without Slowing Their Metabolism
Semaglutide added 12 percent to old mice's median lifespan and matched calorie restriction on aging measures without slowing their metabolism the way dieting does. It was also female mice only, three months of dosing, and zero human longevity data under the fountain-of-youth headlines.
Brain & AgingA Kinesiologist Argues Aging Has a Third Clock, and It Fades First
Georgia Southern's Li Li argues aging has a third clock, movement span, that starts narrowing before any disease shows up. A compelling reframe with one catch: it's an opinion paper carrying zero new data.
Brain & AgingThe Sea Squirt That Reverses Aging Is a Mouse Study From 2022. The Capsules Are Already on Amazon.
The mice got 300 milligrams per kilogram by feeding tube, five days a week, for two months. The human trials used about a milligram a day, most were funded by the companies selling the capsules, and the largest could not beat placebo.
Brain & AgingThe Amino Acid Sold for Focus Tracked Fewer Years for Men, Not Women
In more than 270,000 people, men with higher blood tyrosine died sooner, by nearly a year on the genetic estimate. Women showed no clear lifespan signal. The amino acid is sold in capsules for focus.
Brain & AgingA Stanford Lab Deleted One Immune Receptor and Its Old Mice Barely Aged
Stanford says it found one big reason we age. The proof is a genetically engineered mouse, no such drug exists for people, and the senior author already holds patents on inhibiting the receptor she wants blocked.
Brain & AgingChronic Money Trouble Showed Up on the Brain Scans, Decades Later
In a British cohort followed since birth, people who spent years in the bottom fifth of income had weaker verbal memory by their fifties and larger brain ventricles, a marker of brain aging, by their seventies, even after childhood and education were accounted for.
Infectious DiseaseA Sauna Floods Your Blood With Immune Cells. It's a Flush, Not a Boost.
Fifty-one Finns sat in a 73°C sauna for half an hour, and every white blood cell type poured into their blood. Half an hour later the neutrophils and lymphocytes were back to baseline, and the immune system's chemical alarm had barely rung.
Nutrition & FoodThey Doubled the Recommended Protein This Year. 350 Studies Say That's Backwards for Sedentary Adults.
Federal guidance now tells you to eat nearly twice the protein it used to. A University of Wisconsin review of more than 350 studies argues that for people who don't train hard, the extra may be speeding up the aging they're trying to outrun.
Autoimmune & InflammationA 30-Minute Sauna Floods the Blood With Immune Cells, and the Heat Isn't What Triggers Them
Finnish researchers put 51 people in a 73-degree sauna and watched every class of white blood cell surge, then found the surge had almost nothing to do with how hot anyone actually got.
Brain & AgingSame Diet, Same 15 Pounds: Only the Women Who Ate in an 8-Hour Window Got Sharper
Two groups of older women cut the same calories and lost the same 15 pounds over six months. The ones who packed eating into an 8-hour window still scored better on problem-solving, from a 47-person pilot that hasn't been peer-reviewed.
Metabolic & WeightThe Mice Ate More and Got Leaner. The Switch Was One Amino Acid, Turned Down.
USC mice on a low-protein, methionine-tuned diet ate as many calories as the junk-food group and still lost fat, while their own bodies pumped out more GLP-1. The scientist behind it also owns the company selling longevity diets.
InvestigationsA Pharma-Funded Nonprofit Is Lobbying the FDA to Kill Seven Peptides It Can't Sell You
The Partnership for Safe Medicines has deep ties to the drug lobby. Now it's urging the FDA to permanently block BPC-157, MOTS-c and five other off-patent peptides that compounding pharmacies sell cheap.
Metabolic & WeightOld Muscle Forgets How to Clean Itself. A Gene Called DEAF1 Is Why, and Exercise Silences It.
In aging muscle one gene keeps the growth pathway jammed on and the cleanup crew locked out. Exercise suppresses it in flies and mice, no pill required.